{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T19:31:14Z","timestamp":1786476674751,"version":"build-2736575974"},"reference-count":47,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2008,8,29]],"date-time":"2008-08-29T00:00:00Z","timestamp":1219968000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2008,8,29]],"date-time":"2008-08-29T00:00:00Z","timestamp":1219968000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2008,10,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Inherited myoclonus\u2010dystonia (M\u2010D) is an autosomal dominant disorder characterized by myoclonus and dystonia that often improves with alcohol. To examine the electrophysiologic characteristics of M\u2010D, we studied 6 patients from 4 different families and 9 age\u2010matched healthy subjects. Neurophysiological studies performed include electromyography (EMG)\u2010electroencephalography (EEG) polygraphy, jerk\u2010locked back\u2010averaged EEG, somatosensory evoked potentials (SEP), long\u2010latency reflex (LLR) to median and digital nerve stimulation, and transcranial magnetic stimulation studies with short\u2010interval intracortical inhibition (SICI), intracortical facilitation (ICF), and long\u2010interval intracortical inhibition (LICI). All 6 patients showed myoclonus and dystonia on clinical examination and EMG testing. The EMG burst durations ranged from 30.4 to 750.6 milliseconds (mean, 101.5 milliseconds). Jerk\u2010locked back\u2010averaged EEG failed to reveal any preceding cortical correlates. Median nerve SEP revealed no giant potential. No patients had exaggerated LLR to median or digital nerve stimulation. There was no significant difference in SICI, ICF, and LICI between M\u2010D patients and normal subjects. Myoclonus in inherited M\u2010D is likely of subcortical origin. Normal intracortical inhibition and facilitation suggest that the GABAergic circuits in the motor cortex are largely intact and that the mechanisms of myoclonus and dystonia are different from those for cortical myoclonus and other dystonic disorders. \u00a9 2008 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.22273","type":"journal-article","created":{"date-parts":[[2008,8,29]],"date-time":"2008-08-29T11:42:33Z","timestamp":1220010153000},"page":"2055-2061","source":"Crossref","is-referenced-by-count":44,"title":["Electrophysiological features of myoclonus\u2010dystonia"],"prefix":"10.1002","volume":"23","author":[{"given":"Jie\u2010Yuan","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danny 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