{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T11:16:12Z","timestamp":1788174972218,"version":"build-2803163510"},"reference-count":23,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2008,9,11]],"date-time":"2008-09-11T00:00:00Z","timestamp":1221091200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2008,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Economic evaluation (Italian NHS perspective) modeling <jats:sup>123<\/jats:sup>I\u2010FP\u2010CIT SPECT (DaTSCAN\u00ae) compared to clinical judgment alone for differentiating essential tremor (ET) from Parkinson's Disease (PD). A 5\u2010year Markov model was constructed to assess the cost\u2010effectiveness of <jats:sup>123<\/jats:sup>I\u2010FP\u2010CIT SPECT to differentiate ET from PD in patients referred to a movement disorder specialist in Italy. Published data and a double\u2010round, Delphi panel of 12 specialists populated the model. Effectiveness was expressed as the projected Years on potentially beneficial therapy (PBTYs). Costs were expressed in Euros (2005 values). The model suggests that over 5 years, the \u201ccurrent\u201d diagnostic pathway generated an average of 2.3 PBTYs\/patient at an estimated cost of \u20ac8,864. <jats:sup>123<\/jats:sup>I\u2010FP\u2010CIT SPECT generated an average of 4.1 PBTYs\/patient at an estimated cost of \u20ac8,422, which represented an additional 1.8 PBTYs at a cost saving of \u20ac442\/patient (\u20ac341 when discounted at 5%). The estimated cost\u2010effectiveness of <jats:sup>123<\/jats:sup>I\u2010FP\u2010CIT SPECT is under \u20ac1,000 per PBTY gained when the underlying disease prevalence is high (55\u201370%), and cost\u2010saving at prevalence under 55%. <jats:sup>123<\/jats:sup>I\u2010FP\u2010CIT SPECT is likely to be regarded as economically advantageous to differentiate ET from PD, increasing time on potentially beneficial therapy at a lower overall cost to the healthcare system. \u00a9 2008 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.22278","type":"journal-article","created":{"date-parts":[[2008,9,11]],"date-time":"2008-09-11T15:49:24Z","timestamp":1221148164000},"page":"2202-2209","source":"Crossref","is-referenced-by-count":47,"title":["Cost\u2010effectiveness of <sup>123<\/sup>I\u2010FP\u2010CIT SPECT in the differential diagnosis of essential tremor and Parkinson's disease in Italy"],"prefix":"10.1002","volume":"23","author":[{"given":"Angelo","family":"Antonini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"Berto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Lopatriello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filippo","family":"Tamma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lieven","family":"Annemans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mike","family":"Chambers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,9,11]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.42.10.1901"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.55.9.1358"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21349"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6963-5-26"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/28.2.99"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.57.3.369"},{"key":"e_1_2_6_8_2","doi-asserted-by":"crossref","unstructured":"ScherflerC SchwarzJ AntoniniA et al.Role of DAT\u2010SPECT in the diagnostic work up of Parkinsonism2007;22:1229\u20131238.","DOI":"10.1002\/mds.21505"},{"key":"e_1_2_6_9_2","first-page":"1129","article-title":"SPECT imaging of dopamine transporters in human brain with iodine\u2010123\u2010fluoroalkyl analogs of beta\u2010CIT","volume":"37","author":"Abi\u2010Dargham A","year":"1996","journal-title":"J Nucl Med"},{"key":"e_1_2_6_10_2","first-page":"1500","article-title":"Iodine\u2010123\u2010beta\u2010CIT and iodine\u2010123\u2010FPCIT SPECT measurement of dopamine transporters in healthy subjects and Parkinson's patients","volume":"39","author":"Seibyl JP","year":"1998","journal-title":"J Nucl Med"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01728311"},{"key":"e_1_2_6_12_2","first-page":"1879","article-title":"Imaging of dopamine transporters with iodine\u2010123\u2010FP\u2010CIT in healthy controls and patients with Parkinson's disease","volume":"39","author":"Booij J","year":"1998","journal-title":"J Nucl Med"},{"key":"e_1_2_6_13_2","first-page":"1143","article-title":"Iodine\u2010123\u2010N\u2010omega\u2010fluoropropyl\u20102beta\u2010carbomethoxy\u20103beta\u2010(4\u2010iodophenyl)tropane SPECT in healthy controls and early\u2010stage, drug\u2010naive Parkinson's disease","volume":"39","author":"Tissingh G","year":"1998","journal-title":"J Nucl Med"},{"key":"e_1_2_6_14_2","first-page":"753","article-title":"One\u2010day protocol for imaging of the nigrostriatal dopaminergic pathway in Parkinson's disease by [123I]FP\u2010CIT SPECT","volume":"40","author":"Booij J","year":"1999","journal-title":"J Nucl Med"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20112"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1098-3015(10)61952-3"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8257(200005)15:3<503::AID-MDS1013>3.0.CO;2-V"},{"key":"e_1_2_6_18_2","unstructured":"ISTAT (Istituto Nazionale di Statistica). 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