{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T15:05:56Z","timestamp":1775142356928,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2008,9,29]],"date-time":"2008-09-29T00:00:00Z","timestamp":1222646400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Heinrich-Heine University","award":["9772328"],"award-info":[{"award-number":["9772328"]}]},{"DOI":"10.13039\/501100001663","name":"VolkswagenStiftung","doi-asserted-by":"crossref","award":["I\/80191"],"award-info":[{"award-number":["I\/80191"]}],"id":[{"id":"10.13039\/501100001663","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2009,1,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Resting tremor in idiopathic Parkinson's disease (PD) is associated with an oscillatory network comprising cortical as well as subcortical brain areas. To shed light on the effect of levodopa on these network interactions, we investigated 10 patients with tremor\u2010dominant PD and reanalyzed data in 11 healthy volunteers mimicking PD resting tremor. To this end, we recorded surface electromyograms of forearm muscles and neuromagnetic activity using a 122\u2010channel whole\u2010head magnetometer (MEG). Measurements were performed after overnight withdrawal of levodopa (OFF) and 30 min after oral application of fast\u2010acting levodopa (ON). During OFF, patients showed the typical antagonistic resting tremor. Using the analysis tool <jats:italic>Dynamic Imaging of Coherent Sources<\/jats:italic>, we identified the oscillatory network associated with tremor comprising contralateral primary sensorimotor cortex (S1\/M1), supplementary motor area (SMA), contralateral premotor cortex (PMC), thalamus, secondary somatosensory cortex (S2), posterior parietal cortex (PPC), and ipsilateral cerebellum oscillating at 8 to 10 Hz. After intake of levodopa, we found a significant decrease of cerebro\u2010cerebral coupling between thalamus and motor cortical areas. Similarly, in healthy controls mimicking resting tremor, we found a significant decrease of functional interaction within a thalamus\u2013premotor\u2013motor network during rest. However, in patients with PD, decrease of functional interaction between thalamus and PMC was significantly stronger when compared with healthy controls. These data support the hypothesis that (1) in patients with PD the basal ganglia and motor cortical structures become more closely entrained and (2) levodopa is associated with normalization of the functional interaction between thalamus and motor cortical areas. \u00a9 2008 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.22318","type":"journal-article","created":{"date-parts":[[2008,9,29]],"date-time":"2008-09-29T16:48:18Z","timestamp":1222706898000},"page":"91-98","source":"Crossref","is-referenced-by-count":55,"title":["Levodopa affects functional brain networks in parkinsonian resting tremor"],"prefix":"10.1002","volume":"24","author":[{"given":"Bettina","family":"Pollok","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Houssain","family":"Makhloufi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Butz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joachim","family":"Gross","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Timmermann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Wojtecki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfons","family":"Schnitzler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,1,23]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1650"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.1063"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199810153391607"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3366-04.2004"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awg022"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1995.74.4.1800"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhi084"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2006.06.719"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2003.051235"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)80086-4"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8257(199905)14:3<423::AID-MDS1006>3.0.CO;2-V"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl358"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awf135"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-03-01033.2001"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl103"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awf128"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s100720200033"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0924-980X(97)00085-4"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neucli.2003.10.001"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(06)59022-3"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh480"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200103260-00018"},{"key":"e_1_2_6_24_2","doi-asserted-by":"crossref","first-page":"271","DOI":"10.55782\/ane-2000-1346","article-title":"Synchronised oscillations of the human sensorimotor cortex","volume":"60","author":"Schnitzler A","year":"2000","journal-title":"Acta Neurobiol Exp"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.98.2.694"},{"issue":"2","key":"e_1_2_6_26_2","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0079-6107(96)00009-0","article-title":"A Framework for the analysis of mixed time series\/point process data\u2014theory and application to the study of physiological tremor, single motor unit discharges and electromyograms","volume":"64","author":"Halliday DM","year":"1995","journal-title":"Prog Biophys Mol Biol"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/124.2.378"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2006.03.027"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awf042"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.032682099"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(02)02235-X"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2004.06.001"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0173(94)00007-C"},{"key":"e_1_2_6_34_2","first-page":"9","article-title":"Functional neuroanatomy of the basal ganglia in Parkinson's disease","volume":"91","author":"Wichmann T","year":"2003","journal-title":"Adv Neurol"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/123.7.1459"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.22318","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.22318","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.22318","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T11:21:27Z","timestamp":1760959287000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.22318"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,1,15]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,1,15]]}},"alternative-id":["10.1002\/mds.22318"],"URL":"https:\/\/doi.org\/10.1002\/mds.22318","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"value":"0885-3185","type":"print"},{"value":"1531-8257","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,1,15]]}}}