{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T10:25:41Z","timestamp":1791109541748,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2008,11,17]],"date-time":"2008-11-17T00:00:00Z","timestamp":1226880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2009,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The purpose of this study was to investigate cortical dysfunction in Parkinson's disease (PD) patients with amnestic deficit (PD\u2010MCI). Perfusion single photon emission computed tomography was performed in 15 PD\u2010MCI patients and compared (statistical parametric mapping [SPM2]) with three groups, i.e., healthy subjects (CTR), cognitively intact PD patients (PD), and common amnestic MCI patients (aMCI). Age, depression, and UPDRS\u2010III scores were considered as confounding variables. PD\u2010MCI group (<jats:italic>P<\/jats:italic> &lt; 0.05, false discovery rate\u2013corrected for multiple comparisons) showed relative hypoperfusion in bilateral posterior parietal lobe and in right occipital lobe in comparison to CTR. As compared to aMCI, MCI\u2010PD demonstrated hypoperfusion in bilateral posterior parietal and occipital areas, mainly right cuneus and angular gyrus, and left precuneus and middle occipital gyrus. With a less conservative threshold (uncorrected <jats:italic>P<\/jats:italic> &lt; 0.01), MCI\u2010PD showed hypoperfusion in a left parietal region, mainly including precuneus and inferior parietal lobule, and in a right temporal\u2010parietal\u2010occipital region, including middle occipital and superior temporal gyri, and cuneus\u2010precuneus, as compared to PD. aMCI versus PD\u2010MCI showed hypoperfusion in bilateral medial temporal lobe, anterior cingulate, and left orbitofrontal cortex. PD\u2010MCI patients with amnestic deficit showed cortical dysfunction in bilateral posterior parietal and occipital lobes, a pattern that can be especially recognized versus both controls and common aMCI patients, and to a lesser extent versus cognitively intact PD. The relevance of this pattern in predicting dementia should be evaluated in longitudinal studies. \u00a9 2008 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.22381","type":"journal-article","created":{"date-parts":[[2008,11,17]],"date-time":"2008-11-17T17:06:22Z","timestamp":1226941582000},"page":"414-421","source":"Crossref","is-referenced-by-count":58,"title":["Amnestic mild cognitive impairment in Parkinson's disease: A brain perfusion SPECT study"],"prefix":"10.1002","volume":"24","author":[{"given":"Flavio","family":"Nobili","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Abbruzzese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Morbelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Marchese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Girtler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Dessi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Brugnolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cinzia","family":"Canepa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgos Chr.","family":"Drosos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianmario","family":"Sambuceti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Rodriguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,2,23]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21453"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20974"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.10565"},{"key":"e_1_2_5_5_2","first-page":"797","article-title":"Cerebral metabolic differences in Parkinson's and Alzheimer's disease s matched for dementia severity","volume":"38","author":"Vander Borght T","year":"1997","journal-title":"J Nucl Med"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/123.2.340"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-8119(03)00364-1"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000269666.62598.1c"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mnm.0000243370.18883.62"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-004-1607-5"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(03)00351-X"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa041470"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1177\/0891988705284714"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.2007.00887.x"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000304050.05332.9c"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.56.1.33"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/geront\/10.1_Part_1.20"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/geront\/9.3_Part_1.179"},{"key":"e_1_2_5_19_2","first-page":"89","article-title":"The need of appropriate SPECT templates for SPM comparisons","volume":"52","author":"Morbelli S","year":"2008","journal-title":"Q J Nucl Med Mol Imaging"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1080\/01688638908400920"},{"issue":"8","key":"e_1_2_5_22_2","first-page":"1","article-title":"Standardizzazione e taratura Italiana di test neuropsicologici","volume":"6","author":"Spinnler H","year":"1987","journal-title":"Ital J Neurol Sci"},{"key":"e_1_2_5_23_2","first-page":"189","article-title":"Raven's coloured progressive matrices: normative values on 305 adult normal controls","volume":"2","author":"Basso A","year":"1987","journal-title":"Funct Neurol"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00831566"},{"key":"e_1_2_5_25_2","first-page":"278","article-title":"Tre test clinici di memoria verbale a lungo termine. 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