{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T11:47:32Z","timestamp":1765885652851,"version":"build-2065373602"},"reference-count":11,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2009,1,9]],"date-time":"2009-01-09T00:00:00Z","timestamp":1231459200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2009,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Four Huntington's disease (HD) patients were treated with traditional Chinese medicines Yi\u2010Gan San (YGS) and Chaihu\u2010Jia\u2010Longgu\u2010Muli Tan (CLMT) in a cross\u2010over manner. Two patients took YGS for 8 weeks first, and after 4 weeks of washing out, they took CLMT for 8 weeks. Two other patients took these medicines in reverse order. All patients showed a decrease in the Unified Huntington's Disease Rating Scale\u2014motor assessment (from 106.3 \u00b1 4.7 to 89.6 \u00b1 5.8 as mean \u00b1 SD, <jats:italic>P<\/jats:italic> = 0.0004) by YGS treatment with no extrapiramidal symptoms or changes of cognition or ADL. Our study suggests a possibility of a new treatment for involuntary movements. \u00a9 2009 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.22447","type":"journal-article","created":{"date-parts":[[2009,1,9]],"date-time":"2009-01-09T16:41:46Z","timestamp":1231519306000},"page":"453-455","source":"Crossref","is-referenced-by-count":16,"title":["Traditional Chinese medicine on four patients with Huntington's disease"],"prefix":"10.1002","volume":"24","author":[{"given":"Takashi","family":"Satoh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiyuki","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koh","family":"Iwasaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideaki","family":"Tago","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Seki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuo","family":"Yaegashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muneshige","family":"Tobita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Arai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,2,23]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000204230.16619.d9"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.8.2.141"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v66n0214"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1179\/147683008X301414"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2004.07.013"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870110204"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200508072"},{"key":"e_1_2_6_9_2","unstructured":"KawasakiZ KannoH UekiT et al.Effects of yokukansan on thiamine deficiency\u2010induced decrease in glutamate transport in cultured astrocytes. Presented at the 81st Annual Meeting of the Japanese Pharmacological Society; March 17\u201319 2008; Yokohama Japan. Abstracted in J. Pharmacol. Sci. 2008;106 (Proceeding supplement I):136."},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X01000198"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1211\/0022357991772853"},{"volume-title":"The Foundations of Chinese Medicine","year":"1989","author":"Maciocia G","key":"e_1_2_6_12_2"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.22447","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.22447","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T13:18:13Z","timestamp":1760966293000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.22447"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2,15]]},"references-count":11,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,2,15]]}},"alternative-id":["10.1002\/mds.22447"],"URL":"https:\/\/doi.org\/10.1002\/mds.22447","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"type":"print","value":"0885-3185"},{"type":"electronic","value":"1531-8257"}],"subject":[],"published":{"date-parts":[[2009,2,15]]}}}