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Fifteen patients with PD affected by PG (identified based on DSM\u2010IV criteria; PD+PG) without clinically evident dementia were compared with 15 nondemented patients with PD not affected by PG (PD\u2212PG). Two groups of patients with PD were matched for age, length of education, and gender. Clinical and neuropsychiatric features were assessed; several cognitive domains, mainly related to executive functions, were explored by means of standardized neuropsychological tasks. PD+PG and PD\u2212PG did not differ on clinical and neuropsychiatric aspects. PD+PG patients performed significantly worse than PD\u2212PG patients on cognitive tasks that evaluated visuo\u2010spatial long\u2010term memory and several frontal lobe functions. After Bonferroni correction, differences remained significant on the Frontal Assessment Battery (FAB) (<jats:italic>P<\/jats:italic> = 0.001), on phonological fluency task (<jats:italic>P<\/jats:italic> = 0.003), and on the Trail Making Test, part B minus part A (<jats:italic>P<\/jats:italic> = 0.002). Logistic regression analysis demonstrated that low scores on the FAB were the only independent predictor of PG (odds ratio, 27.9; 95% CI: 2.82\u2013277.95, <jats:italic>P<\/jats:italic> = 0.004). The results indicate an association between PG and frontal lobe dysfunctions in nondemented patients with PD. Low scores on the FAB indicate patients with PD at high risk for PG. \u00a9 2009 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.22472","type":"journal-article","created":{"date-parts":[[2009,2,9]],"date-time":"2009-02-09T17:37:05Z","timestamp":1234201025000},"page":"899-905","source":"Crossref","is-referenced-by-count":79,"title":["Cognitive dysfunctions and pathological gambling in patients with Parkinson's 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