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To determine whether similar histopathology occurs in 1\u2010methyl\u20104\u2010phenyl\u20101,2,3,6\u2010tetrahydropyridine (MPTP)\u2010primate models over a similar timeframe, the brains of two adult monkeys made parkinsonian in their youth with intermittent injections of MPTP were studied. Despite substantial nigral degeneration and increased \u03b1\u2010synuclein immunoreactivity within surviving neurons, there was no evidence of Lewy body formation. 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