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Early HD subjects had statistically significantly (<jats:italic>P<\/jats:italic> = 0.007) increased (threefold higher) rates of whole\u2010brain atrophy compared with controls. Higher atrophy rates were associated with longer CAG repeat length. MRI\u2010based measures of whole\u2010brain atrophy may have potential as a measure of progression in HD. \u00a9 2009 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.22485","type":"journal-article","created":{"date-parts":[[2009,2,25]],"date-time":"2009-02-25T15:04:47Z","timestamp":1235574287000},"page":"932-936","source":"Crossref","is-referenced-by-count":41,"title":["Whole\u2010brain atrophy as a measure of progression in premanifest and early Huntington's disease"],"prefix":"10.1002","volume":"24","author":[{"given":"Susie M.D.","family":"Henley","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward J.","family":"Wild","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola 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