{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T12:20:15Z","timestamp":1763036415844,"version":"build-2065373602"},"reference-count":298,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2009,5,1]],"date-time":"2009-05-01T00:00:00Z","timestamp":1241136000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Jackstaedt Fellowship des Stifterverbandes fuer die Deutsche Wissenschaft"},{"DOI":"10.13039\/100006309","name":"American Parkinson Disease Association","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100006309","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000864","name":"Michael J. Fox Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000864","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2009,7,30]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In recent years, the neurochemical analysis of neuronal proteins in cerebrospinal fluid (CSF) has become increasingly accepted for the diagnosis of neurodegenerative dementia diseases such as Alzheimer's disease and Creutzfeldt\u2013Jakob disease. CSF surrounds the central nervous system, and in the composition of CSF proteins one finds brain\u2010specific proteins that are prioritized from blood\u2010derived proteins. Levels of specific CSF proteins could be very promising biomarkers for central nervous system diseases. We need the development of more easily accessible biomarkers, in the blood. In neurodegenerative diseases with and without dementia, studies on CSF and blood proteins have investigated the usefulness of biomarkers in differential diagnosis. The clinical diagnoses of Parkinson's disease, dementia with Lewy bodies, multiple system atrophy, progressive supranuclear palsy, and corticobasal degeneration still rely mainly on clinical symptoms as defined by international classification criteria. In this article, we review CSF biomarkers in these movement disorders and discuss recent published reports on the neurochemical intra vitam diagnosis of neurodegenerative disorders (including recent CSF \u03b1\u2010synuclein findings). \u00a9 2009 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.22510","type":"journal-article","created":{"date-parts":[[2009,5,1]],"date-time":"2009-05-01T16:17:24Z","timestamp":1241194644000},"page":"1411-1426","source":"Crossref","is-referenced-by-count":34,"title":["Neurochemical biomarkers in the differential diagnosis of movement disorders"],"prefix":"10.1002","volume":"24","author":[{"given":"Brit","family":"Mollenhauer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Trenkwalder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,5]]},"reference":[{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-199806000-00010"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1080\/15622970510029786"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(07)70178-3"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20009"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/359325a0"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410380413"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(94)90298-4"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-8981(01)00573-3"},{"volume-title":"Neurlogische Labordiagnostik","year":"2006","author":"Reiber H","key":"e_1_2_11_10_2"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(00)00501-3"},{"key":"e_1_2_11_12_2","doi-asserted-by":"crossref","first-page":"12670","DOI":"10.1016\/S0021-9258(19)86366-4","article-title":"Conservation of microtubule associated proteins. 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