{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T12:20:31Z","timestamp":1763036431081,"version":"build-2065373602"},"reference-count":18,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2009,7,30]],"date-time":"2009-07-30T00:00:00Z","timestamp":1248912000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Fondo de Investigaci\u00f3n Sanitaria","award":["FIS 05\/1056","06\/1252","RETICS RD07\/0064\/0016"],"award-info":[{"award-number":["FIS 05\/1056","06\/1252","RETICS RD07\/0064\/0016"]}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003351","name":"FUNDESALUD","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003351","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Consejer\u00eda de Sanidad y Consumo"},{"DOI":"10.13039\/501100014181","name":"Junta de Extremadura","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100014181","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2009,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To investigate the possible association between dopamine receptor D3 genotype (<jats:italic>DRD3<\/jats:italic>) and allelic variants and the risk for developing essential tremor (ET). Leukocytary DNA from 201 patients with ET and 282 healthy controls was studied for the genotype <jats:italic>DRD3<\/jats:italic> and the occurrence of <jats:italic>DRD3<\/jats:italic> allelic variants by using allele\u2010specific PCR amplification and <jats:italic>Msl<\/jats:italic>I\u2010RFLP's analyses. A meta\u2010analysis of previous studies was performed. The frequencies of the <jats:italic>DRD3Ser\/Gly<\/jats:italic> genotype and of the allelic variant <jats:italic>DRDGly<\/jats:italic> were significantly higher in patients with ET than in controls (<jats:italic>P<\/jats:italic> &lt; 0.017 and &lt;0.005, respectively), These findings were especially relevant in women (OR = 1.73, 95% CI: 1.15\u20132.59, <jats:italic>P<\/jats:italic> = 0.008), and in patients with earlier onset of the disease with (<jats:italic>P<\/jats:italic> = 0.014). The frequencies of the <jats:italic>DRD3Ser\/Gly<\/jats:italic> and <jats:italic>DRD3Gly\/Gly<\/jats:italic> genotypes and of the allelic variant <jats:italic>DRD3Gly<\/jats:italic> in patients were significantly higher in patients with voice tremor, but not with head, tongue, or chin tremor, than in controls. The meta\u2010analysis indicated association of variant genotypes with ET risk (OR = 1.18, 95% CI 1.01\u20131.38). These results suggest that <jats:italic>DRD3<\/jats:italic> genotype and the variant <jats:italic>DRD3Gly<\/jats:italic> allelic variant is associated with the risk for and age at onset of ET, and with the risk for voice tremor, in Caucasian Spanish people. \u00a9 2009 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.22518","type":"journal-article","created":{"date-parts":[[2009,7,30]],"date-time":"2009-07-30T16:12:59Z","timestamp":1248970379000},"page":"1910-1915","source":"Crossref","is-referenced-by-count":24,"title":["Dopamine receptor D3 (DRD3) genotype and allelic variants and risk for essential tremor"],"prefix":"10.1002","volume":"24","author":[{"given":"Elena","family":"Garc\u00eda\u2010Mart\u00edn","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hortensia","family":"Alonso\u2010Navarro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juli\u00e1n","family":"Benito\u2010Le\u00f3n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inmaculada","family":"Puertas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lluisa","family":"Rubio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom\u00e1s","family":"L\u00f3pez\u2010Alburquerque","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 A. G.","family":"Ag\u00fandez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F\u00e9lix Javier","family":"Jim\u00e9nez\u2010Jim\u00e9nez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,10,21]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.45.4.645"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1353-8020(97)00031-X"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1159\/000103646"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(05)00991-9"},{"key":"e_1_2_7_6_2","first-page":"833","volume-title":"Tratado de los trastornos del movimiento","author":"Alonso\u2010Navarro H","year":"2008"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0997-84"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870120605"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl120"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.2006.00600.x"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0508189103"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20950"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000256773.87498.2f"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2007.11.002"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2008.02164.x"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2008.02225.x"},{"issue":"3","key":"e_1_2_7_17_2","first-page":"2","article-title":"Consensus statement of the Movement Disorder Society on tremor. Ad Hoc Scientific Committee","volume":"13","author":"Deuschl G","year":"1998","journal-title":"Mov Disord"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/26.2.147"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.10376"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.22518","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.22518","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.22518","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T11:28:41Z","timestamp":1760959721000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.22518"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,10,15]]},"references-count":18,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2009,10,15]]}},"alternative-id":["10.1002\/mds.22518"],"URL":"https:\/\/doi.org\/10.1002\/mds.22518","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"type":"print","value":"0885-3185"},{"type":"electronic","value":"1531-8257"}],"subject":[],"published":{"date-parts":[[2009,10,15]]}}}