{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T08:08:11Z","timestamp":1778314091472,"version":"3.51.4"},"reference-count":19,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2009,5,1]],"date-time":"2009-05-01T00:00:00Z","timestamp":1241136000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000368","name":"Brain Research Trust, UK","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000368","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2009,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Adverse events of dopamine\u2010blocking agents include acute dystonic reactions and oculogyric crises (OGCs). OGCs may be recurrent on maintenance of or re\u2010exposure to the drug. Thus, complete withdrawal is recommended. Recurrent episodes of acute dystonia despite withdrawal and the lack of further exposure to antidopaminergic agents are usually not seen. Here, we report three cases with recurrent OGCs despite complete withdrawal of neuroleptics. Triggering or priming factors were a single dose of haloperidol in two cases and a single dose of metoclopramide in one case. Episodes reoccurred spontaneously, but responded to anticholinergics. The pathomechanisms of acute dystonic reactions and OGCs remain unclear. Parallels to levodopa\u2010induced dyskinesias in Parkinson's disease, as well as to dopa\u2010responsive dystonia, paroxysmal dyskinesias, and channelopathies are discussed here. Whether there is a genetic susceptibility or some other reason for only some patients developing this phenomenon remains unclear. \u00a9 2009 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.22532","type":"journal-article","created":{"date-parts":[[2009,5,1]],"date-time":"2009-05-01T16:22:57Z","timestamp":1241194977000},"page":"1226-1229","source":"Crossref","is-referenced-by-count":25,"title":["Recurrent acute dystonic reaction and oculogyric crisis despite withdrawal of dopamine receptor blocking drugs"],"prefix":"10.1002","volume":"24","author":[{"given":"Susanne A.","family":"Schneider","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vrajesh","family":"Udani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charulata Sawant","family":"Sankhla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kailash P.","family":"Bhatia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,6,18]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1C389"},{"key":"e_1_2_7_3_2","volume-title":"Drug\u2010induced Movement Disorders","author":"Sethi KD","year":"2006"},{"key":"e_1_2_7_4_2","first-page":"137","volume-title":"Drug\u2010induced neurological disorders","author":"Jain KK","year":"1996"},{"key":"e_1_2_7_5_2","first-page":"111","volume-title":"Drug\u2010Induced Movement Disorders","author":"Bhatt M","year":"2006"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.4103\/0253-7613.16864"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870080117"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20722"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.52.8.1714"},{"key":"e_1_2_7_10_2","first-page":"1100","article-title":"[The syndrome of bilateral paramedian thalamic infarction associated with an oculogyric crisis]","volume":"26","author":"Kakigi R","year":"1986","journal-title":"Rinsho Shinkeigaku"},{"key":"e_1_2_7_11_2","first-page":"40","article-title":"[Retrocollis and oculogyric crisis in association with bilateral putaminal hemorrhages]","volume":"33","author":"Shimpo T","year":"1993","journal-title":"Rinsho Shinkeigaku"},{"key":"e_1_2_7_12_2","first-page":"105","volume-title":"Movement disorders in children: a clinical update with video recordings","author":"Zorzi G","year":"2007"},{"key":"e_1_2_7_13_2","first-page":"550","article-title":"Recurrent dystonic reactions induced by thiethylperazine","volume":"19","author":"Khanderia U","year":"1985","journal-title":"Drug Intell Clin Pharm"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22280"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(01)01039-6"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2004.02.011"},{"key":"e_1_2_7_17_2","first-page":"160","article-title":"Acute dystonic reaction to metoclopramide in patients carrying homozygous cytochrome P450 2D6 genetic polymorphisms","volume":"64","author":"van der PA","year":"2006","journal-title":"Neth J Med"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2008.154294"},{"key":"e_1_2_7_19_2","first-page":"459","volume-title":"Parkinson's disease and movement disorders","author":"Schneider SA","year":"2006"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncpneuro0178"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.22532","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.22532","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.22532","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T14:23:13Z","timestamp":1760970193000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.22532"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,6,15]]},"references-count":19,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2009,6,15]]}},"alternative-id":["10.1002\/mds.22532"],"URL":"https:\/\/doi.org\/10.1002\/mds.22532","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"value":"0885-3185","type":"print"},{"value":"1531-8257","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,6,15]]}}}