{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:09:39Z","timestamp":1792782579013,"version":"4.5.0"},"reference-count":18,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2009,4,7]],"date-time":"2009-04-07T00:00:00Z","timestamp":1239062400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Brain Imaging Center West","id":[{"id":"https:\/\/ror.org\/05hsqsk33","id-type":"ROR","asserted-by":"crossref"}]},{"name":"German Federal Ministry for Education and Research","award":["BMBF, grant 01 GI9934"],"award-info":[{"award-number":["BMBF, grant 01 GI9934"]}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"crossref","award":["DFG, Klinische Forschergruppe 112"],"award-info":[{"award-number":["DFG, Klinische Forschergruppe 112"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"crossref","award":["HO2402\/6-1"],"award-info":[{"award-number":["HO2402\/6-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]},{"name":"International Consortium for Brain Mapping"},{"name":"Willy Robert Pitzer Foundation"},{"name":"von behring|r\u00f6ntgen|stiftung","award":["56-0039"],"award-info":[{"award-number":["56-0039"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2009,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    A dysfunction of multiple neurotransmitter systems is assumed as a neurochemical basis of the akinetic\u2010rigid syndrome of progressive supranuclear palsy (PSP). In vitro studies have produced conflicting results on the serotoninergic system in PSP. We, therefore, studied the binding potential of the serotonin 2A (5\u2010HT\n                    <jats:sub>2A<\/jats:sub>\n                    ) receptor ligand [F]altanserin in 8 patients with clinically probable PSP and 13 healthy controls using positron emission tomography. We found an up\u2010regulation of 5\u2010HT\n                    <jats:sub>2A<\/jats:sub>\n                    receptors in the substantia nigra and, to a lower degree, in the striatum, while neocortical 5\u2010 HT\n                    <jats:sub>2A<\/jats:sub>\n                    receptor densities showed no changes upon partial\u2010volume correction. Nigral and striatal receptor changes were significantly correlated with patients' scores of motor dysfunction (UPDRS III, PSP\u2010rating scale) pointing to a functional relevance of the described findings. \u00a9 2009 Movement Disorder Society\n                  <\/jats:p>","DOI":"10.1002\/mds.22533","type":"journal-article","created":{"date-parts":[[2009,4,7]],"date-time":"2009-04-07T16:38:41Z","timestamp":1239122321000},"page":"1170-1175","source":"Crossref","is-referenced-by-count":15,"title":["Nigrostriatal upregulation of 5\u2010HT\n                    <sub>2A<\/sub>\n                    receptors correlates with motor dysfunction in progressive supranuclear palsy"],"prefix":"10.1002","volume":"24","author":[{"given":"Maria","family":"Stamelou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Matusch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Elmenhorst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9","family":"Hurlemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karla M.","family":"Eggert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl","family":"Zilles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang H.","family":"Oertel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fcnter 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based morphometry reveals a distinct pattern of frontal atrophy in progressive supranuclear palsy","volume":"75","author":"Brenneis C","year":"2004","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/1096-9861(20010122)429:4<571::AID-CNE5>3.0.CO;2-X"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(99)02237-4"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1998.tb10229.x"}],"container-title":["Movement 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