{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T09:40:46Z","timestamp":1774518046559,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"S2","license":[{"start":{"date-parts":[[2009,10,28]],"date-time":"2009-10-28T00:00:00Z","timestamp":1256688000000},"content-version":"vor","delay-in-days":300,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2009,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Clinical criteria enable accurate and reliable diagnosis of parkinsonian syndromes when cardinal clinical features are fully developed. Single photon emission computed tomography (SPECT) investigating the striatal dopamine transporter (DAT) status have been suggested to increase the diagnostic accuracy in uncertain parkinsonian syndromes such as isolated tremor symptoms not fulfilling essential tremor criteria, as well as drug\u2010induced, vascular and psychogenetic parkinsonism. Several approaches for the analysis of the striatal DAT distribution have been tested for their ability to analyze and quantify SPECT images. Visual assessment of DAT binding and semiquantitative analysis using region of interests have been recommended by Nuclear Medicine Associations to be incorporated in the routine work\u2010up of DAT\u2010SPECT. Besides these observer dependent approaches, fully automated image\u2010analysis techniques have been validated in the clinical setting. Their potential as tools to improve the diagnostic accuracy in patients presenting with parkinsonian features is reviewed here. \u00a9 2009 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.22590","type":"journal-article","created":{"date-parts":[[2010,7,8]],"date-time":"2010-07-08T17:15:08Z","timestamp":1278609308000},"source":"Crossref","is-referenced-by-count":32,"title":["Dopamine transporter SPECT: How to remove subjectivity?"],"prefix":"10.1002","volume":"24","author":[{"given":"Christoph","family":"Scherfler","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Nocker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,10,28]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awf080"},{"issue":"10","key":"e_1_2_7_3_2","first-page":"S34","article-title":"What features improve the accuracy of clinical diagnosis in Parkinson's disease: a clinicopathologic study. 1992","volume":"57","author":"Hughes AJ","year":"2001","journal-title":"Neurology"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.42.6.1142"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0317167100031814"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-7091-6360-3_14"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-6147(93)90029-J"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8257(200007)15:4<692::AID-MDS1014>3.0.CO;2-V"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8257(200005)15:3<503::AID-MDS1013>3.0.CO;2-V"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.2005.00517.x"},{"key":"e_1_2_7_11_2","first-page":"393","article-title":"Sensitivity and specificity of 99mTc\u2010TRODAT\u20101 SPECT imaging in differentiating patients with idiopathic Parkinson's disease from healthy subjects","volume":"45","author":"Weng YH","year":"2004","journal-title":"J Nucl Med"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.1256"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-7091-6842-4_2"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/51\/3\/007"},{"key":"e_1_2_7_15_2","first-page":"1175","article-title":"Age\u2010related decline in striatal dopamine transporter binding with iodine\u2010123\u2010beta\u2010CITSPECT","volume":"36","author":"van Dyck CH","year":"1995","journal-title":"J Nucl Med"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajgp.10.1.36"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006231-200106000-00017"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.10531"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.1265"},{"key":"e_1_2_7_20_2","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1212\/WNL.57.11.2089","article-title":"[123I]beta\u2010CIT SPECT imaging assessment of the rate of Parkinson's disease progression","volume":"57","author":"Marek K","year":"2001","journal-title":"Neurology"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.287.13.1653"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa033447"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1994.131"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1992.tb25974.x"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/syn.890120105"},{"key":"e_1_2_7_26_2","unstructured":"Available at:https:\/\/www eanm org\/."},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.106.037432"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006231-200512000-00015"},{"key":"e_1_2_7_29_2","first-page":"1109","article-title":"Clinical testing of an optimized software solution for an automated, observer\u2010independent evaluation of dopamine transporter SPECT studies","volume":"46","author":"Koch W","year":"2005","journal-title":"J Nucl Med"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/51\/12\/004"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.106.038646"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.460030303"},{"key":"e_1_2_7_33_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh485"},{"key":"e_1_2_7_34_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.63.8.1154"},{"key":"e_1_2_7_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870120203"},{"key":"e_1_2_7_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(03)00662-8"},{"key":"e_1_2_7_37_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/117.2.235"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.22590","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.22590","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T09:48:08Z","timestamp":1760953688000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.22590"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,1]]},"references-count":36,"journal-issue":{"issue":"S2","published-print":{"date-parts":[[2009,1]]}},"alternative-id":["10.1002\/mds.22590"],"URL":"https:\/\/doi.org\/10.1002\/mds.22590","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"value":"0885-3185","type":"print"},{"value":"1531-8257","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,1]]}}}