{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T17:27:23Z","timestamp":1791998843482,"version":"4.4.0"},"reference-count":45,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2009,5,13]],"date-time":"2009-05-13T00:00:00Z","timestamp":1242172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"NIH","award":["Protocol: # 1 R01 HD043770)"],"award-info":[{"award-number":["Protocol: # 1 R01 HD043770)"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2009,7,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Gait dysfunction is an early problem identified by patients with Parkinson's disease (PD). Alterations in gait may result in an increase in the energy cost of walking (i.e., walking economy). The purpose of this study was to determine whether walking economy is atypical in patients with PD when compared with healthy controls. A secondary purpose was to evaluate the associations of age, sex, and level of disease severity with walking economy in patients with PD. The rate of oxygen consumption (V\u0307O\n                    <jats:sub>2<\/jats:sub>\n                    ) and other responses to treadmill walking were compared in 90 patients (64.4 \u00b1 10.3 years) and 44 controls (64.6 \u00b1 7.3 years) at several walking speeds. Pearson correlation coefficients (r) were calculated to determine relationships of age, sex, and disease state with walking economy in PD patients. Walking economy was significantly worse in PD patients than in controls at all speeds above 1.0 mph. Across all speeds, V\u0307O\n                    <jats:sub>2<\/jats:sub>\n                    was 6 to 10% higher in PD patients. Heart rate, minute ventilation, respiratory exchange ratio, and rating of perceived exertion were correspondingly elevated. No significant relationship of age, sex, or UPDRS score with V\u0307O\n                    <jats:sub>2<\/jats:sub>\n                    was found for patients with PD. The findings suggest that the physiologic stress of daily physical activities is increased in patients with early to mid\u2010stage PD, and this may contribute to the elevated level of fatigue that is characteristic of PD. \u00a9 2009 Movement Disorder Society\n                  <\/jats:p>","DOI":"10.1002\/mds.22621","type":"journal-article","created":{"date-parts":[[2009,5,13]],"date-time":"2009-05-13T16:44:35Z","timestamp":1242233075000},"page":"1481-1487","source":"Crossref","is-referenced-by-count":89,"title":["Walking economy in people with Parkinson's disease"],"prefix":"10.1002","volume":"24","author":[{"given":"Cory L.","family":"Christiansen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret L.","family":"Schenkman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"McFann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela","family":"Wolfe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy M.","family":"Kohrt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,5,13]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21879"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1109\/TNSRE.2007.908933"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/ptj\/80.6.578"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21853"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21922"},{"key":"e_1_2_7_7_2","first-page":"508","article-title":"Interrelationships between mechanical power, energy transfers, and walking and running economy","volume":"25","author":"Martin PE","year":"1993","journal-title":"Med Sci Sports Exerc"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0966-6362(99)00009-0"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1249\/01.mss.0000222829.34111.9c"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9993(03)00373-3"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gaitpost.2004.04.005"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/BPO.0b013e318093f4c3"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/ptj\/76.1.34"},{"key":"e_1_2_7_14_2","first-page":"165","article-title":"Parkinson's Disease Society Brain Bank, London: overview and research","volume":"39","author":"Daniel SE","year":"1993","journal-title":"J Neural Transm Suppl"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.2007.00818.x"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1249\/00005768-198205000-00012"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.10473"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0258(19971030)16:20<2349::AID-SIM667>3.0.CO;2-E"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005768-199906000-00001"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2006.05033.x"},{"issue":"7","key":"e_1_2_7_21_2","first-page":"VII2","article-title":"The natural history of Parkinson's disease","volume":"253","author":"Poewe W","year":"2006","journal-title":"J Neurol"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.301.6763.1256"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1042\/cs0830199"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1249\/00005768-199204000-00013"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/117.5.1169"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00094.2003"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01106.2002"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2002-33034"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/138.2.266"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.PHM.0000133436.61009.02"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1999.86.6.1785"},{"key":"e_1_2_7_32_2","first-page":"150","article-title":"Mitochondrial dysfunction in Parkinson's disease\u2010\u2010revisited","volume":"41","author":"Mortiboys HJ","year":"2007","journal-title":"Neurol Neurochir Pol"},{"key":"e_1_2_7_33_2","doi-asserted-by":"publisher","DOI":"10.1515\/BC.1999.106"},{"key":"e_1_2_7_34_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-003-1105-z"},{"key":"e_1_2_7_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(03)00555-6"},{"key":"e_1_2_7_36_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-133-5-200009050-00009"},{"key":"e_1_2_7_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gaitpost.2006.07.003"},{"key":"e_1_2_7_38_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20507"},{"key":"e_1_2_7_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(89)90532-8"},{"key":"e_1_2_7_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2004.11.008"},{"key":"e_1_2_7_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejheart.2004.05.006"},{"key":"e_1_2_7_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2007.05.015"},{"key":"e_1_2_7_43_2","first-page":"231","article-title":"A randomised controlled cross\u2010over trial of aerobic training versus Qigong in advanced Parkinson's disease","volume":"42","author":"Burini D","year":"2006","journal-title":"Eura Medicophys"},{"key":"e_1_2_7_44_2","doi-asserted-by":"publisher","DOI":"10.1053\/apmr.2002.34603"},{"key":"e_1_2_7_45_2","doi-asserted-by":"publisher","DOI":"10.2522\/ptj.20060351"},{"key":"e_1_2_7_46_2","doi-asserted-by":"publisher","DOI":"10.3233\/NRE-2002-17209"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.22621","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.22621","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.22621","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T09:50:13Z","timestamp":1760953813000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.22621"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,5,13]]},"references-count":45,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2009,7,30]]}},"alternative-id":["10.1002\/mds.22621"],"URL":"https:\/\/doi.org\/10.1002\/mds.22621","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"value":"0885-3185","type":"print"},{"value":"1531-8257","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,5,13]]}}}