{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T02:02:57Z","timestamp":1786672977196,"version":"build-2736575974"},"reference-count":34,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2009,6,9]],"date-time":"2009-06-09T00:00:00Z","timestamp":1244505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2009,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Parkinson's disease (PD) with autonomic dysfunction is difficult to differentiate from Parkinsonism\u2010predominant multiple system atrophy (MSA\u2010p). This study aimed to analyze the validity of MIBG scintigraphy for PD with autonomic dysfunction and MSA\u2010p. Thirty\u2010nine patients (PD: 27 patients, MSA\u2010p type: 12) and 12 age\u2010matched controls were prospectively enrolled and underwent MIBG scintigraphy and autonomic function test (AFT). We separately calculated early and delayed heart\u2010to\u2010mediastinal (<jats:italic>H<\/jats:italic>\/<jats:italic>M<\/jats:italic>) ratio and washout rates (WRs). AFT was composed of sympathetic skin reflex and parasympathetic tests based on heart rate variability. Abnormal AFT was observed in 17 (63%) of PD and 10 (83%) of MSA\u2010p. On comparing PD with abnormal AFT with MSA\u2010p, either the early or delayed <jats:italic>H<\/jats:italic>\/<jats:italic>M<\/jats:italic> ratio in PD was not different from that in MSA\u2010p (<jats:italic>P<\/jats:italic> &gt; 0.05). Only the WR could differentiate PD with abnormal AFT from MSA\u2010p (47.07 \u00b1 57.48 vs. 31.39 \u00b1 31.52, respectively) (<jats:italic>P<\/jats:italic> = 0.026). According to the results, WR may be more useful than the early and delayed <jats:italic>H<\/jats:italic>\/<jats:italic>M<\/jats:italic> ratio to distinguish MSA\u2010p from PD with abnormal AFT. Furthermore, the MIBG uptake did not reflect the disease duration or severity. \u00a9 2009 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.22649","type":"journal-article","created":{"date-parts":[[2009,6,9]],"date-time":"2009-06-09T15:52:36Z","timestamp":1244562756000},"page":"1650-1655","source":"Crossref","is-referenced-by-count":52,"title":["MIBG scintigraphy for differentiating Parkinson's disease with autonomic dysfunction from Parkinsonism\u2010predominant multiple system atrophy"],"prefix":"10.1002","volume":"24","author":[{"given":"Eun Joo","family":"Chung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won Yong","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won Tae","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byeong 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