{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T08:05:51Z","timestamp":1791187551913,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2009,6,26]],"date-time":"2009-06-26T00:00:00Z","timestamp":1245974400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004332","name":"Seoul National University Hospital","doi-asserted-by":"crossref","award":["03-2008-015"],"award-info":[{"award-number":["03-2008-015"]}],"id":[{"id":"10.13039\/501100004332","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Shinyang Cultural Foundation"},{"name":"Korea Health 21 R&D Project"},{"name":"Ministry of Health and Welfare, Republic of Korea","award":["03-PJ10-PG13-GD01-0002"],"award-info":[{"award-number":["03-PJ10-PG13-GD01-0002"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2009,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    We aimed to assess whether allelic variants of dopamine receptor, glutamate receptor, and serotonin transporter genes are associated with the appearance of impulse control and related behaviors (ICRB) in Parkinson's disease (PD) with dopamine replacement therapy (DRT). We surveyed ICRB in consecutive Korean patients with PD who were treated with stable DRT using modified Minnesota Impulsive Disorders Interview over a period of 4 months. In the 404 patients who completed the interview and the 559 Korean healthy normal controls, genotyping was performed for variants of the\n                    <jats:italic>DRD3<\/jats:italic>\n                    p.S9G,\n                    <jats:italic>DRD2<\/jats:italic>\n                    <jats:italic>Taq1A, GRIN2B<\/jats:italic>\n                    c.366C&gt;G, c.2664C&gt;T and c.\u2010200T&gt;G, and the promoter region of the serotonin transporter gene (5\u2010HTTLPR). Behavioral abnormalities suggestive of ICRB including compulsive buying, gambling, sexual behavior and eating, and punding, were present in 14.4% of the patients. Variants of\n                    <jats:italic>DRD2<\/jats:italic>\n                    and 5\u2010HTTLPR were not associated with the risk of developing ICRB. However, the AA genotype of\n                    <jats:italic>DRD3<\/jats:italic>\n                    p.S9G and the CC genotype of\n                    <jats:italic>GRIN2B<\/jats:italic>\n                    c.366C&gt;G were more frequent in patients with ICRB than in nonaffected patients (odds ratio [OR] = 2.21,\n                    <jats:italic>P<\/jats:italic>\n                    = 0.0094; and 2.14,\n                    <jats:italic>P<\/jats:italic>\n                    = 0.0087, after adjusting for age and sex). After controlling for clinical variables in the multivariate analysis, carriage of either AA genotype of\n                    <jats:italic>DRD3<\/jats:italic>\n                    or CC genotype of\n                    <jats:italic>GRIN2B<\/jats:italic>\n                    was identified as an independent risk factor for ICRB (adjusted OR: 2.57,\n                    <jats:italic>P<\/jats:italic>\n                    = 0.0087). Variants of\n                    <jats:italic>DRD3<\/jats:italic>\n                    p.S9G and\n                    <jats:italic>GRIN2B<\/jats:italic>\n                    c.366C&gt;G may be associated with the appearance of ICRB in PD. \u00a9 2009 Movement Disorder Society\n                  <\/jats:p>","DOI":"10.1002\/mds.22678","type":"journal-article","created":{"date-parts":[[2009,6,26]],"date-time":"2009-06-26T16:30:36Z","timestamp":1246033836000},"page":"1803-1810","source":"Crossref","is-referenced-by-count":148,"title":["Association of\n                    <i>DRD3<\/i>\n                    and\n                    <i>GRIN2B<\/i>\n                    with impulse control and related behaviors in Parkinson's disease"],"prefix":"10.1002","volume":"24","author":[{"given":"Jee\u2010Young","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Kyung","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Sup","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji\u2010Yeon","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee Jin","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Sun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beom S","family":"Jeon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,6,26]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1444.006"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.64.8.1089"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000218206.20920.4d"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000238503.20816.13"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20045"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.63.7.969"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21872"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.64.2.212"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2007.06.043"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/347146a0"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1996.1296"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4000350"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.256.5060.1217"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4000808"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2006.08.007"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(99)00171-7"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2006.06.016"},{"key":"e_1_2_7_19_2","first-page":"5","article-title":"Compulsive 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