{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T11:19:26Z","timestamp":1761823166622,"version":"build-2065373602"},"reference-count":15,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2009,8,11]],"date-time":"2009-08-11T00:00:00Z","timestamp":1249948800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Department of Neurogenetics and Molecular Biology"},{"name":"Instituto Nacional de Neurolog\u00eda y Neurocirug\u00eda Manuel Velasco Su\u00e1rez, Mexico City, Mexico"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2009,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We report the characteristics of 691 Mexican patients with Huntington's disease (HD). These patients, representing 401 families, constitute the largest series of Mexican HD cases as yet described in the literature. We found the clinical characteristics of these patients to be similar to those of other populations, but we observed a higher frequency of infantile cases, a shorter disease duration and a lower suicide rate. In 626 cases, for which molecular analyses were available, CAG\u2010trinucleotide expansion size ranged from 37\u2013106 repeats. The large number of CAG repeats (19.04 \u00b1 3.02) in normal alleles and the presence of new mutations suggest that the overall prevalence of HD in the Mexican population could be expected to be within range of, or higher than, that reported for Europeans. \u00a9 2009 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.22737","type":"journal-article","created":{"date-parts":[[2009,8,11]],"date-time":"2009-08-11T16:33:41Z","timestamp":1250008421000},"page":"2012-2015","source":"Crossref","is-referenced-by-count":37,"title":["Clinical and genetic characteristics of Mexican Huntington's disease patients"],"prefix":"10.1002","volume":"24","author":[{"given":"Mar\u00eda Elisa","family":"Alonso","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana","family":"Ochoa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie\u2010Catherine","family":"Boll","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Luisa","family":"Sosa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petra","family":"Yescas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marisol","family":"L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosario","family":"Macias","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Itziar","family":"Familiar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Astrid","family":"Rasmussen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,10,21]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1086\/301846"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199405193302001"},{"key":"e_1_2_7_4_2","first-page":"159","volume-title":"Huntington's disease","author":"Harper PS","year":"2002"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10038-007-0227-1"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1997.tb02459.x"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/3.12.2103"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0004.2002.610607.x"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0004.2003.00093.x"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2000-7461"},{"key":"e_1_2_7_11_2","doi-asserted-by":"crossref","first-page":"223","DOI":"10.2310\/7010.2006.00055","article-title":"Clinical characteristics of childhood\u2010onset (juvenile) Huntington disease: report of 12 patients and review of the literature","volume":"21","author":"Gonzalez\u2010Alegre P","year":"2006","journal-title":"J Child Neurol"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.64.6.813"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2008.09.029"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.162.4.725"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awg077"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.2006.00668.x"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.22737","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.22737","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.22737","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T11:28:32Z","timestamp":1760959712000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.22737"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,10,15]]},"references-count":15,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2009,10,15]]}},"alternative-id":["10.1002\/mds.22737"],"URL":"https:\/\/doi.org\/10.1002\/mds.22737","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"type":"print","value":"0885-3185"},{"type":"electronic","value":"1531-8257"}],"subject":[],"published":{"date-parts":[[2009,10,15]]}}}