{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T01:51:47Z","timestamp":1778032307503,"version":"3.51.4"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2010,2,19]],"date-time":"2010-02-19T00:00:00Z","timestamp":1266537600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2010,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Patient\u2010based measures of subjective health status are increasingly used as outcome measures in interventional trials. We aimed to determine the variability and predictors of subjective health ratings in a possible target group for future interventions: the spinocerebellar ataxias (SCAs). A consecutive sample of 526 patients with otherwise unexplained progressive ataxia and genetic diagnoses of SCA1 (117), SCA2 (163), SCA3 (139), and SCA6 (107) were enrolled at 18 European referral centers. Subjective health status was assessed with a generic measure of health related quality of life, the EQ\u20105D (Euroqol) questionnaire. In addition, we performed a neurological examination and a screening questionnaire for affective disorders (patient health questionnaire). Patient\u2010reported health status was compromised in patients of all genotypes (EQ\u20105D visual analogue scale (EQ\u2010VAS) mean 61.45 \u00b1 20.8). Specifically, problems were reported in the dimensions of mobility (86.9% of patients), usual activities (68%), pain\/discomfort (49.4%), depression\/anxiety (46.4%), and self care (38.2%). Multivariate analysis revealed three independent predictors of subjective health status: ataxia severity, extent of noncerebellar involvement, and the presence of depressive syndrome. This model explained 30.5% of EQ\u2010VAS variance in the whole sample and might be extrapolated to other SCA genotypes. \u00a9 2010 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.22740","type":"journal-article","created":{"date-parts":[[2010,2,19]],"date-time":"2010-02-19T12:59:55Z","timestamp":1266584395000},"page":"587-595","source":"Crossref","is-referenced-by-count":89,"title":["Self\u2010rated health status in spinocerebellar ataxia\u2014Results from a European multicenter 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