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The objective of this study was to determine whether spirals drawn by patients with Niemann\u2010Pick disease type C (NPC) could be distinguished from those of controls, and to physiologically characterize movement abnormalities in NPC. Spiral data consisting of position, pressure, and time were collected from 14 NPC patients and 14 age\u2010matched controls, and were analyzed by the Mann\u2010Whitney <jats:italic>U<\/jats:italic> test. NPC spirals were characterized by: lower speed (2.67 vs. 9.56 cm\/s, <jats:italic>P<\/jats:italic> &lt; 0.001) and acceleration (0.10 vs. 2.04 cm\/s<jats:sup>2<\/jats:sup>, <jats:italic>P<\/jats:italic> &lt; 0.001), higher loop width variability (0.88 vs. 0.28, <jats:italic>P<\/jats:italic> &lt; 0.001), tremor (5\/10 vs. 0\/10 trials in the dominant hand, <jats:italic>P<\/jats:italic> &lt; 0.001), and poor overall spiral rating (2.53 vs. 0.70, <jats:italic>P<\/jats:italic> &lt; 0.005). NPC spirals also exhibited sustained drawing pressure profiles that were abnormally invariant with time. Other features, such as the tightness of loop widths, were normal. Our findings reveal that differing aspects of tremor, Parkinsonism, ataxia, and dystonia are quantifiable in NPC patients. \u00a9 2009 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.22744","type":"journal-article","created":{"date-parts":[[2009,8,11]],"date-time":"2009-08-11T16:32:48Z","timestamp":1250008368000},"page":"1984-1990","source":"Crossref","is-referenced-by-count":26,"title":["Spiral analysis in Niemann\u2010Pick disease type C"],"prefix":"10.1002","volume":"24","author":[{"given":"Annie W.","family":"Hsu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Panida A.","family":"Piboolnurak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alicia G.","family":"Floyd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiping 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