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Serotonin neurons have the capacity to store and release dopamine synthesized from systemically administered levodopa. However, because of the lack of any autoregulatory feedback control, dopamine released from serotonin terminals results in excessive swings in extracellular dopamine levels after peripheral administration of levodopa. Such \u201cdysregulated\u201d release of levodopa\u2010derived dopamine is likely to be responsible for the appearance of the abnormal movements in levodopa\u2010primed animals. This mechanism may also play a role in the development of graft\u2010induced dyskinesias in patients that receive fetal neuron transplants, possibly due to the inclusion of serotonin neurons in the grafted ventral midbrain tissue, which contribute to maintain dopamine receptors of the denervated striatum in a supersensitive state. \u00a9 2010 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.22792","type":"journal-article","created":{"date-parts":[[2010,2,25]],"date-time":"2010-02-25T16:53:59Z","timestamp":1267116839000},"source":"Crossref","is-referenced-by-count":63,"title":["Role of serotonin neurons in the induction of levodopa\u2010 and graft\u2010induced dyskinesias in Parkinson's 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