{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:47:25Z","timestamp":1791298045723,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2009,11,4]],"date-time":"2009-11-04T00:00:00Z","timestamp":1257292800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2009,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Hyposmia is a common nonmotor feature of Parkinson's disease (PD) and has been variably detected in monogenic Parkinsonisms. To assess olfactory dysfunction in\n                    <jats:italic>PINK1<\/jats:italic>\n                    \u2010related Parkinsonism, we evaluated olfactory detection threshold, odor discrimination, and odor identification in five groups of subjects: sporadic PD (n = 19),\n                    <jats:italic>PINK1<\/jats:italic>\n                    homozygous (n = 7), and heterozygous (n = 6) parkinsonian patients, asymptomatic\n                    <jats:italic>PINK1<\/jats:italic>\n                    heterozygous carriers (n = 12), and Italian healthy subjects (n = 67). All affected subjects and all healthy heterozygotes but one resulted hyposmic, with most patients in the range of functional anosmia or severe hyposmia. Detection threshold was more preserved and discrimination more impaired in patients with\n                    <jats:italic>PINK1<\/jats:italic>\n                    mutations than in PD cases. Alterations of detection and discrimination were observed also in\n                    <jats:italic>PINK1<\/jats:italic>\n                    asymptomatic heterozygotes. On the contrary, odor identification appeared to be mostly related to the disease status, as it was impaired in nearly all patients (including PD and\n                    <jats:italic>PINK1<\/jats:italic>\n                    cases) and preserved in healthy heterozygotes. Our data indicate that olfactory dysfunction is common in\n                    <jats:italic>PINK1<\/jats:italic>\n                    Parkinsonism and consists typically in defective odor identification and discrimination. A milder olfactory deficit, mostly involving discrimination, can be found in asymptomatic heterozygotes, possibly indicating an underlying preclinical neurodegenerative process. \u00a9 2009 Movement Disorder Society\n                  <\/jats:p>","DOI":"10.1002\/mds.22816","type":"journal-article","created":{"date-parts":[[2009,11,4]],"date-time":"2009-11-04T17:13:49Z","timestamp":1257354829000},"page":"2350-2357","source":"Crossref","is-referenced-by-count":44,"title":["Olfactory dysfunction in Parkinsonism caused by\n                    <i>PINK1<\/i>\n                    mutations"],"prefix":"10.1002","volume":"24","author":[{"given":"Alessandro","family":"Ferraris","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara","family":"Ialongo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulio Cesare","family":"Passali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Teresa","family":"Pellecchia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Livia","family":"Brusa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianna","family":"Laruffa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arianna","family":"Guidubaldi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaetano","family":"Paludetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Albanese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Barone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Dallapiccola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enza Maria","family":"Valente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Rita","family":"Bentivoglio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,12,18]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2008.12.005"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.50.1.88"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.38.8.1237"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.55.2.138"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.1049"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20141"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20160"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21413"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21291"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870100309"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awf251"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.44.2.266"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1998.tb10631.x"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8257(200101)16:1<41::AID-MDS1017>3.0.CO;2-M"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.60.4.545"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21490"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22155"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(75)90058-2"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.33.7.943"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.10379"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.wco.0000137531.76491.c2"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000118281.66802.81"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000336651.48596.c7"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.49.5.1262"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.1221"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21525"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(08)70117-0"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000326575.20829.45"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20256"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl005"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.65.6.802"},{"key":"e_1_2_7_33_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000323812.40708.1f"},{"key":"e_1_2_7_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21960"},{"key":"e_1_2_7_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/humu.20719"},{"key":"e_1_2_7_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2006.08.009"},{"key":"e_1_2_7_37_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10417"},{"key":"e_1_2_7_38_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1096284"},{"key":"e_1_2_7_39_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000163999.72864.FD"},{"key":"e_1_2_7_40_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.42.6.1142"},{"key":"e_1_2_7_41_2","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1177\/014556130007900515","article-title":"The role of rhinomanometry, acoustic rhinometry, and mucociliary transport time in the assessment of nasal patency","volume":"79","author":"Passali D","year":"2000","journal-title":"Ear Nose Throat J"},{"key":"e_1_2_7_42_2","doi-asserted-by":"publisher","DOI":"10.1093\/chemse\/22.1.39"},{"key":"e_1_2_7_43_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-006-0173-0"},{"key":"e_1_2_7_44_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22325"},{"key":"e_1_2_7_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)81209-X"},{"key":"e_1_2_7_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2007.09.056"},{"key":"e_1_2_7_47_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl114"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.22816","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.22816","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T11:23:08Z","timestamp":1760959388000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.22816"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12,15]]},"references-count":46,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2009,12,15]]}},"alternative-id":["10.1002\/mds.22816"],"URL":"https:\/\/doi.org\/10.1002\/mds.22816","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"value":"0885-3185","type":"print"},{"value":"1531-8257","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,12,15]]}}}