{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T17:51:00Z","timestamp":1791049860104,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2009,11,24]],"date-time":"2009-11-24T00:00:00Z","timestamp":1259020800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Korean Ministry of Education, Science and Technology","award":["FPR08B1-170"],"award-info":[{"award-number":["FPR08B1-170"]}]},{"name":"21C Frontier Functional Proteomics Program"},{"name":"Korea Healthcare Technology R&D Project"},{"name":"Ministry for Health, Welfare and Family Affairs, Republic of Korea","award":["Project No.: A080256"],"award-info":[{"award-number":["Project No.: A080256"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2010,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We investigated whether homocysteine (Hcy)\u2010 lowering therapy or an antioxidant prevented bone loss in Parkinson's disease (PD) patients taking levodopa. Forty\u2010two PD patients with low bone mineral density (BMD) taking levodopa were randomly assigned to Hcy\u2010lowering therapy (5 mg folate and 1500 \u03bcg vitamin B<jats:sub>12<\/jats:sub> daily), \u03b1\u2010lipoic acid (\u03b1\u2010LA) therapy (1200 mg daily), or control groups. Primary outcomes were BMD changes from baseline to 12 months. Secondary outcomes were changes in Hcy level, and C\u2010telopeptide (CTX) levels at 12 months. Forty\u2010one patients completed the study. Hcy\u2010lowering therapy resulted in significantly greater BMD changes at the lumbar spine (4.4%), total femur (2.8%), and femur shaft (2.8%) than control (<jats:italic>P<\/jats:italic> = 0.005\u20130.023). BMD changes in the \u03b1\u2013LA therapy group were similar to those of the control group, but changes at the trochanter (4.6%) were significantly greater in the \u03b1\u2013LA therapy group than in the control group after adjustment for body mass index changes. Hcy concentrations decreased to 35.2% \u00b1 13.4% in the Hcy\u2010lowering therapy group, but increased in other groups. Serum CTX levels at 12 months tended to be lower in the Hcy\u2010lowering group (0.442 \u00b1 0.024 ng\/mL) than control group (0.628 \u00b1 0.039 ng\/mL) (<jats:italic>P<\/jats:italic> = 0.159). This small trial suggests that Hcy\u2010lowering therapy may prevent bone loss in PD patients taking levodopa. \u00a9 2009 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.22866","type":"journal-article","created":{"date-parts":[[2009,11,24]],"date-time":"2009-11-24T15:50:49Z","timestamp":1259077849000},"page":"332-340","source":"Crossref","is-referenced-by-count":32,"title":["Homocysteine\u2010lowering therapy or antioxidant therapy for bone loss in Parkinson's disease"],"prefix":"10.1002","volume":"25","author":[{"given":"Seung Hun","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi Jung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beom\u2010Jun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Reul","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sail","family":"Chun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Sook","family":"Ryu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghi Su","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myoung Chong","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung\u2010Min","family":"Koh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun Ju","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,2,24]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afh203"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/21.1.32"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2004.52410.x"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(00)00458-5"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2004.04.012"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.49.5.1273"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.66.1.64"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006231-199403000-00010"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/24.4.326"},{"key":"e_1_2_7_11_2","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1093\/clinchem\/47.6.1102","article-title":"Plasma homocysteine and L\u2010dopa metabolism in patients with Parkinson disease","volume":"47","author":"Blandini F","year":"2001","journal-title":"Clin Chem"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000055899.24594.8E"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20253"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0404.2003.00135.x"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.60.1.59"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.166.1.88"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2004.04.018"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2005.04.017"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032739"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2005.01.011"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032546"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2005.053363"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.060406"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.293.9.1082"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1677\/joe.1.05995"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.55.3.181"},{"key":"e_1_2_7_27_2","volume-title":"Physician's guide to prevention and treatment of osteoporosis","author":"National Osteoporosis Foundation","year":"2003"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.2165\/00024677-200403030-00005"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.17.5.427"},{"key":"e_1_2_7_30_2","series-title":"Recent developments in Parkinson's disease","first-page":"153","author":"Fahn S","year":"1987"},{"key":"e_1_2_7_31_2","first-page":"518","article-title":"Assessing vertebral fractures. 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