{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:50:06Z","timestamp":1786978206603,"version":"build-2736575974"},"reference-count":10,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2010,3,3]],"date-time":"2010-03-03T00:00:00Z","timestamp":1267574400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Ortho-McNeil Janssen Scientific Affairs, LLC, USA"},{"name":"Johnson & Johnson Pharmaceutical Research and Development, LLC"},{"name":"INC Research, Inc.","award":["RWJ-333369"],"award-info":[{"award-number":["RWJ-333369"]}]},{"name":"SK Biopharmaceuticals, under development for the treatment of epilepsy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2010,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The efficacy and safety of carisbamate, an investigational neuromodulator currently in development for epilepsy, were examined in a multicenter, randomized, double\u2010blind, cross\u2010over, placebo\u2010controlled study of essential tremor. Sixty\u2010two patients (intent\u2010to\u2010treat analysis set; mean age 64 years; 66% men) received carisbamate 400 mg\/day or matching placebo in a crossover study design with two 21\u2010day treatment periods. The Fahn\u2010Tolosa\u2010Mar\u00edn Tremor Rating Scale (TRS) was the primary assessment tool. Carisbamate and placebo treatment did not differ in their effect on the TRS (\n                    <jats:italic>P<\/jats:italic>\n                    = 0.94) or on measures of affect, mood, or quality of life. Carisbamate was generally well tolerated and had an adverse event profile comparable to that of placebo. \u00a9 2010 Movement Disorder Society\n                  <\/jats:p>","DOI":"10.1002\/mds.22872","type":"journal-article","created":{"date-parts":[[2010,3,3]],"date-time":"2010-03-03T11:42:07Z","timestamp":1267616527000},"page":"634-638","source":"Crossref","is-referenced-by-count":16,"title":["Carisbamate in essential tremor: Brief report of a proof of concept study"],"prefix":"10.1002","volume":"25","author":[{"given":"Rodger J.","family":"Elble","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Biondi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"Ascher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Wiegand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Hulihan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,4,21]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.2165\/0023210-200822120-00006"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2006.00814.x"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000334751.89859.7f"},{"key":"e_1_2_8_5_2","article-title":"Carisbamate as adjunctive treatment of partial onset seizures in adults in two international, randomized, placebo\u2010controlled trials","author":"Sperling M","year":"2009","journal-title":"Epilepsia"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2008.09.006"},{"issue":"3","key":"e_1_2_8_7_2","first-page":"2","article-title":"Consensus statement of the Movement Disorder Society on Tremor. Ad Hoc Scientific Committee","volume":"13","author":"Deuschl G","year":"1998","journal-title":"Mov Disord"},{"key":"e_1_2_8_8_2","first-page":"225","volume-title":"Parkinson's disease and movement disorders","author":"Fahn S","year":"1993"},{"key":"e_1_2_8_9_2","volume-title":"Manual: Profile of Mood States","author":"McNair DM","year":"1971"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/014662167700100306"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2005.05.009"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.22872","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.22872","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.22872","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:13:49Z","timestamp":1760955229000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.22872"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,4,15]]},"references-count":10,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2010,4,15]]}},"alternative-id":["10.1002\/mds.22872"],"URL":"https:\/\/doi.org\/10.1002\/mds.22872","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"value":"0885-3185","type":"print"},{"value":"1531-8257","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,4,15]]}}}