{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T18:03:39Z","timestamp":1789236219856,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2010,1,8]],"date-time":"2010-01-08T00:00:00Z","timestamp":1262908800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"German Ministry of Education and Research","award":["BMBF Nr. 01GI9901\/1"],"award-info":[{"award-number":["BMBF Nr. 01GI9901\/1"]}]},{"name":"Competence Network Parkinson's disease"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2010,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To investigate the health\u2010related quality of life (HrQoL) of adult patients with Gilles de la Tourette's syndrome (GTS) in Germany. HrQoL was evaluated in 200 adult patients with GTS (Mean age: 34.9 \u00b1 11.8 years). Patients were recruited from three outpatient departments in Germany and completed a semi\u2010structured, self\u2010rating interview. HrQoL was measured using the EQ\u20105D. Depression was assessed using the Beck's depression inventory (BDI) and clinical symptoms using the Yale Tourette syndrome symptom list (TSSL) and the Shapiro Tourette\u2010syndrome severity scale (STSSS). Multivariate regression analyses were performed to identify independent predictors of HrQoL. Patients with GTS proved to have a worse HrQoL than a sample from the general German population. The domains most affected were anxiety\/depression (57.1%), followed by pain\/discomfort (47.5%), usual activities (38.4%), mobility (14%), and self\u2010care (6.6%). The mean EQ\u20105D visual analog scale (EQ\u2010VAS) was 65.4 \u00b1 21.9. The patients had a mean BDI score of 12.3 \u00b1 9.9, which was considerably worse compared to a healthy group who had a score of 6.45 \u00b1 5.2. The mean STSSS value was 3.2 \u00b1 1.1. In multivariate analyses, depressive symptoms contributed considerably, whereas the severity of symptoms as well as age only contributed minimally to HrQoL in the model (R<jats:sup>2<\/jats:sup> = 0.54). HrQoL is considerably reduced in adult patients with GTS. The main independent factors for determining HrQoL were depression, severity of symptoms, and age. Although, treatment of tics is important, co\u2010morbidities such as depression should be diagnosed and treated vigorously. \u00a9 2009 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.22900","type":"journal-article","created":{"date-parts":[[2010,1,8]],"date-time":"2010-01-08T18:39:20Z","timestamp":1262975960000},"page":"309-314","source":"Crossref","is-referenced-by-count":94,"title":["Health\u2010related quality of life in patients with Gilles de la Tourette's syndrome"],"prefix":"10.1002","volume":"25","author":[{"given":"Kirsten","family":"M\u00fcller\u2010Vahl","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ines","family":"Dodel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"M\u00fcnchau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens Peter","family":"Reese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Balzer\u2010Geldsetzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Dodel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang H.","family":"Oertel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,2,24]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"crossref","first-page":"161","DOI":"10.31887\/DCNS.2007.9.2\/nmueller","article-title":"Tourette's syndrome: clinical features, pathophysiology, and therapeutic approaches","volume":"9","author":"Muller N","year":"2007","journal-title":"Dialog Clin Neurosci"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2008.03.006"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2000.tb00346.x"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/123.3.425"},{"key":"e_1_2_7_6_2","volume-title":"Tourette\u2010syndrome\u2010severity scale","author":"Shapiro AK","year":"1988"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-198907000-00015"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000327890.02893.61"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.2001.00147.x"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1080\/15374410701279545"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22487"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0168-8510(90)90421-9"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.69.1.67"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2008.01.002"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-2-20"},{"key":"e_1_2_7_16_2","volume-title":"Beck\u2010depressions\u2010inventar (BDI)","author":"Hautzinger M","year":"2005"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0272-7358(88)90050-5"},{"key":"e_1_2_7_18_2","volume-title":"Beck depression inventory: manual","author":"Beck A","year":"1987"},{"key":"e_1_2_7_19_2","first-page":"55","volume-title":"Tourette's syndrome and tic disorders: clinical understanding and treatment","author":"Leckman JF","year":"1988"},{"key":"e_1_2_7_20_2","first-page":"3","volume-title":"The clinical guide to child psychiatry","author":"Cohen D","year":"1985"},{"key":"e_1_2_7_21_2","volume-title":"Handbook of Tourette's syndrome and related tic and behavioral disorders","author":"Kurlan R","year":"2005"},{"key":"e_1_2_7_22_2","unstructured":"EuroQol\u2010Group. 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