{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T19:53:11Z","timestamp":1762113191110,"version":"build-2065373602"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2010,1,8]],"date-time":"2010-01-08T00:00:00Z","timestamp":1262908800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"NIH"},{"DOI":"10.13039\/100000065","name":"NINDS","doi-asserted-by":"crossref","award":["#NS R01-35284"],"award-info":[{"award-number":["#NS R01-35284"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"crossref"}]},{"name":"General Clinical Research Centers","award":["RR00052","RR00645","RR00042","RR00044","RR01066","RR07122"],"award-info":[{"award-number":["RR00052","RR00645","RR00042","RR00044","RR01066","RR07122"]}]},{"name":"Astra-Zeneca"},{"name":"Vitaline"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2010,1,30]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Uric acid (UA) may be associated with the progression of Parkinson's disease and related neurodegenerative conditions; however, its association with Huntington's disease (HD) progression has not been explored. A secondary analysis of 347 subjects from the CARE\u2010HD clinical trial was performed to examine the relationship between baseline UA levels and the level of functional decline in HD. Outcomes included change in scores at 30 months for the Unified Huntington's Disease Rating Scale components. There was less worsening of total functional capacity over time with increasing baseline UA levels (adjusted mean worsening in scores: 3.17, 2.99, 2.95, 2.28, 2.21, from lowest to highest UA quintile, <jats:italic>P<\/jats:italic> = 0.03). These data suggest a possible association between higher UA levels and slower HD progression, particularly as measured by total functional capacity. If confirmed, UA could be an important predictor and potentially modifiable factor affecting the rate of HD progression. \u00a9 2009 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.22907","type":"journal-article","created":{"date-parts":[[2010,1,8]],"date-time":"2010-01-08T18:59:51Z","timestamp":1262977191000},"page":"224-228","source":"Crossref","is-referenced-by-count":73,"title":["The relationship between uric acid levels and Huntington's disease progression"],"prefix":"10.1002","volume":"25","author":[{"given":"Peggy","family":"Auinger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl","family":"Kieburtz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael P.","family":"Mcdermott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,2,24]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.78.11.6858"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20624"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4547(19980901)53:5<613::AID-JNR11>3.0.CO;2-1"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/gps.1469"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20663"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(92)90191-M"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.2008.65.6.nct70003"},{"key":"e_1_2_7_9_2","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1212\/WNL.57.3.397","article-title":"A randomized, placebo\u2010controlled trial of coenzyme Q10 and remacemide in Huntington's disease","volume":"57","author":"The Huntington Study Group","year":"2001","journal-title":"Neurology"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870110204"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1080\/13854049608406667"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3932(90)90096-7"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1076\/clin.13.3.348.1749"},{"key":"e_1_2_7_14_2","first-page":"134","volume-title":"The Neuropsychological handbook.","author":"Reitan R","year":"1986"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.2044-8260.1967.tb00530.x"},{"key":"e_1_2_7_16_2","first-page":"271","volume-title":"Quantification of neurologic deficit","author":"Shoulson I","year":"1989"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21988"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/9781119013563"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2006.8.2061"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.22907","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.22907","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.22907","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T08:48:21Z","timestamp":1760950101000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.22907"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,1,30]]},"references-count":18,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,1,30]]}},"alternative-id":["10.1002\/mds.22907"],"URL":"https:\/\/doi.org\/10.1002\/mds.22907","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"type":"print","value":"0885-3185"},{"type":"electronic","value":"1531-8257"}],"subject":[],"published":{"date-parts":[[2010,1,30]]}}}