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These were long considered epileptic until video\u2010EEG in Patients 1 and 3 revealed their non\u2010epileptic nature. A primary dystonic mechanism was suspected and Patients 1 and 2 were treated with Trihexyphenidyl with significantly reduced frequency of the ALTEs. Patient 3 died before Trihexyphenidyl was tried. Trihexyphenidyl in RS patients with similar presentations can modify the dystonia and prevent ALTEs. \u00a9 2009 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.22926","type":"journal-article","created":{"date-parts":[[2010,1,8]],"date-time":"2010-01-08T18:58:25Z","timestamp":1262977105000},"page":"385-389","source":"Crossref","is-referenced-by-count":10,"title":["Trihexyphenidyl for acute life\u2010threatening episodes due to a dystonic movement disorder in Rett syndrome"],"prefix":"10.1002","volume":"25","author":[{"given":"Artemis D.","family":"Gika","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elaine","family":"Hughes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sushma","family":"Goyal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Sparkes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Pierre","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,2,24]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1053\/ejpn.2002.0612"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21744"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870050303"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/08830738050200090801"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22115"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21276"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2008.05.003"},{"key":"e_1_2_5_9_2","first-page":"467","article-title":"Altered neurochemical markers in Rett syndrome","volume":"26","author":"Wenk GL","year":"1989","journal-title":"Ann Neurol"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2005.02.012"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.85.1.29"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1991.00530140106023"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2006.10.003"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2006.09.003"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2004.00845.x"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.33.10.1255"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60849-1"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.22926","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.22926","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.22926","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T12:23:15Z","timestamp":1760962995000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.22926"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,2,15]]},"references-count":16,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010,2,15]]}},"alternative-id":["10.1002\/mds.22926"],"URL":"https:\/\/doi.org\/10.1002\/mds.22926","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"value":"0885-3185","type":"print"},{"value":"1531-8257","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,2,15]]}}}