{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T19:25:05Z","timestamp":1791401105506,"version":"4.3.3"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2010,1,8]],"date-time":"2010-01-08T00:00:00Z","timestamp":1262908800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100001262","name":"National Parkinson Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100001262","id-type":"DOI","asserted-by":"crossref"}]},{"name":"NPF Center of Excellence at Baylor College of Medicine"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2010,1,30]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We describe the clinical course and postmortem pathological findings in a patient with essential tremor (ET) treated with deep brain stimulation (DBS) for 12 years. This 75 year old woman had a 13\u2010year history of progressive ET prior to implantation of bilateral quadripolar DBS electrodes in the region of her ventral intermediate thalamic nuclei in 1996, producing immediate relief of arm tremor. Histopathological examination of the brain, performed 12 years after the initial implantation, demonstrated electrode catheter tracts rimmed by 20\u201025 micron fibrous sheaths, with multinucleated giant cells and reactive gliosis. Lymphocytic infiltration was seen by L26 immunoreactivity with CD3 (T cells) staining predominating over CD20 (B cells). Cerebellar axonal spheroids and Purkinje cell loss were found. The minimal foreign body reaction and gliosis around the electrodes 12 years after implantation supports the long\u2010term safety of DBS. The case represents the longest reported follow\u2010up with autopsy examination after DBS and confirmed histological changes associated with ET. \u00a9 2009 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.22935","type":"journal-article","created":{"date-parts":[[2010,1,8]],"date-time":"2010-01-08T18:45:09Z","timestamp":1262976309000},"page":"232-238","source":"Crossref","is-referenced-by-count":46,"title":["Long\u2010term deep brain stimulation for essential tremor: 12\u2010year clinicopathologic follow\u2010up"],"prefix":"10.1002","volume":"25","author":[{"given":"Daniel J.","family":"DiLorenzo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Jankovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard K.","family":"Simpson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidehiro","family":"Takei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne Z.","family":"Powell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,2,24]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2007.106.4.621"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2003.10.033"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000310426.18409.11"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2006.104.4.506"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.1249"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21788"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2000.93.1.0140"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A0744"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410410108"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870040210"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200002173420703"},{"key":"e_1_2_8_13_2","first-page":"39","article-title":"Chronic VIM thalamic stimulation in Parkinson's disease, essential tremor, and extra\u2010pyramidal dyskinesias","volume":"58","author":"Benabid A","year":"1993","journal-title":"Acta Neurochir Suppl"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11940-999-0027-3"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.63.8.1189"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2007.8"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21731"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm266"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.56.11.1576"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2006.112334"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2007.05.002"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.22935","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.22935","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.22935","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T08:48:37Z","timestamp":1760950117000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.22935"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,1,30]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,1,30]]}},"alternative-id":["10.1002\/mds.22935"],"URL":"https:\/\/doi.org\/10.1002\/mds.22935","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"value":"0885-3185","type":"print"},{"value":"1531-8257","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,1,30]]}}}