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Here, we undertook a detailed prospective clinical, neuropsychological, and neuroimaging analysis of 14 consecutive patients presenting with PNFA to identify cases meeting clinical criteria for PSP. These patients had further detailed assessment of extrapyramidal and oculomotor functions. All patients had high\u2010resolution MR brain volumetry and a cortical thickness analysis was undertaken on the brain images. Four patients presenting with PNFA subsequently developed features of a PSP syndrome, including a typical oculomotor palsy. The neuropsychological profile in these cases was similar to other patients with PNFA, however, with more marked reduction in propositional speech, fewer speech errors, less marked impairment of literacy skills but more severe associated deficits of episodic memory and praxis. These PSP\u2010PNFA cases had less prominent midbrain atrophy but more marked prefrontal atrophy than a comparison group of five patients with pathologically confirmed PSP without PNFA and more prominent midbrain atrophy but less marked perisylvian atrophy than other PNFA cases. In summary, although the PSP\u2010PNFA syndrome overlaps with PNFA without PSP, certain neuropsychological and neuroanatomical differences may help predict the development of a PSP syndrome. \u00a9 2010 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.22946","type":"journal-article","created":{"date-parts":[[2010,1,13]],"date-time":"2010-01-13T14:45:06Z","timestamp":1263393906000},"page":"179-188","source":"Crossref","is-referenced-by-count":81,"title":["Progressive supranuclear palsy syndrome presenting as progressive nonfluent aphasia: A neuropsychological and neuroimaging analysis"],"prefix":"10.1002","volume":"25","author":[{"given":"Jonathan D.","family":"Rohrer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominic","family":"Paviour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adolfo M.","family":"Bronstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean S.","family":"O'Sullivan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Lees","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason D.","family":"Warren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,2,24]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.51.6.1546"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10825"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000081230.09863.ED"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0b013e3283168ddd"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1159\/000068502"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1080\/13554790590963004"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl078"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1080\/13554790601125957"},{"key":"e_1_2_7_10_2","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1007\/s00401-003-0682-5","article-title":"Progressive supranuclear palsy presenting with primary progressive aphasia\u2014clinicopathological report of an autopsy case","volume":"105","author":"Mochizuki A","year":"2003","journal-title":"Acta Neuropathologica"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2990.2000.00266-2.x"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm251"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.55.11.1621"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.47.1.1"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.10459"},{"issue":"5","key":"e_1_2_7_17_2","first-page":"256","article-title":"Neuroprotection and natural history in Parkinson plus syndromes (NNIPPS): construction and validation of a functional scale for disease progression assessment in Parkinson plus syndromes, progressive supranuclear palsy (PSP) and multiple system atrophy (MSA)","volume":"17","author":"Payan CVM","year":"2002","journal-title":"Mov Disord"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000249307.59950.f8"},{"key":"e_1_2_7_19_2","volume-title":"Manual for Raven's progressive matrices and vocabulary scales. 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