{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:50:06Z","timestamp":1786978206534,"version":"build-2736575974"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2010,2,3]],"date-time":"2010-02-03T00:00:00Z","timestamp":1265155200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Medtronic, Inc."},{"DOI":"10.13039\/100005616","name":"Allergan, Inc.","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100005616","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2010,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Many adults with intellectual disabilities (ID) have spasticity, where increased muscle tone impairs activities of daily living (ADL) self\u2010performance and care delivery. There are few reports of spasticity treatment for people with ID, and none of functionally meaningful outcomes. Our objective is to determine the effect of comprehensive spasticity management on ADL self\u2010performance and care delivery. Baseline evaluation included repeated modified Ashworth and range of motion assessments, and timed and videotaped care task observations. Spasticity treatment was initiated immediately thereafter. Follow\u2010up evaluation was conducted after spasticity management was optimized, one year after initiation. All individuals with spasticity at a single developmental center for whom treatment goals could be identified were included. Treatment was recommended by a neurologist from any accepted treatment for spasticity except oral medications, including botulinum neurotoxin A, intrathecal baclofen and orthopedic procedures. The main outcome measure is comparison of ease of videotaped care delivery, rated by direct caregivers blinded to participant treatment status. Spasticity treatment resulted in significant improvement across all outcome measures. Range of motion improved by 9\u00b0 (\n                    <jats:italic>P<\/jats:italic>\n                    = 0.005) and MAS by 0.4 (\n                    <jats:italic>P<\/jats:italic>\n                    = 0.022). Participants took 14% percent less time to complete tasks post\u2010treatment (\n                    <jats:italic>P<\/jats:italic>\n                    = 0.01). Thirteen caregivers completed evaluations of 35 video pairs with an intra\u2010class correlation of 0.9. After treatment, undergarment change (\n                    <jats:italic>P<\/jats:italic>\n                    = 0.031) and shirt change (\n                    <jats:italic>P<\/jats:italic>\n                    = 0.017) were rated easier, and all goals (\n                    <jats:italic>P<\/jats:italic>\n                    = 0.0006). Transfers trended toward improvement (\n                    <jats:italic>P<\/jats:italic>\n                    = 0.053). This study shows comprehensive spasticity management provides meaningful improvement in ADL care for patients with ID, which may improve quality of life and reduce caregiver burden. \u00a9 2010 Movement Disorder Society\n                  <\/jats:p>","DOI":"10.1002\/mds.22995","type":"journal-article","created":{"date-parts":[[2010,2,3]],"date-time":"2010-02-03T17:02:35Z","timestamp":1265216555000},"page":"466-473","source":"Crossref","is-referenced-by-count":12,"title":["Spasticity treatment facilitates direct care delivery for adults with profound intellectual disability"],"prefix":"10.1002","volume":"25","author":[{"given":"P. David","family":"Charles","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandler E.","family":"Gill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry M.","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael S.","family":"Putman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CaraLee R.","family":"Blair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda G.","family":"Roberts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory D.","family":"Ayers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter E.","family":"Konrad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,3,16]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9993(03)00368-X"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/0883073896011001S01"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1023\/B:APBI.0000026639.95223.6f"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2004.tb01013.x"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-1331.2001.00045.x"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2004.tb00511.x"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrdd.20149"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1348\/135910705X43769"},{"key":"e_1_2_7_10_2","unstructured":"USDHHS.Closing the gap: a national blueprint to improve the health of persons with mental retardation. Report of the Surgeon General's Conference on Health Disparities and Mental Retardation 2002. Available athttp:\/\/www.nichd.nih.gov\/publications\/pubs\/closingthegap"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.72.11.1226"},{"key":"e_1_2_7_12_2","first-page":"239","article-title":"Managing the care of patients with mental retardation: a survey of physicians","volume":"31","author":"Minihan PM","year":"1993","journal-title":"Ment Retard"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197811092991904"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.83.6.481"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0887-8994(03)00269-8"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1080\/02699050400013675"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1053\/apmr.2002.35474"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1080\/09638280400014634"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.PHM.0000141128.62598.81"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1037\/0033-2909.86.2.420"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrdd.20065"},{"key":"e_1_2_7_22_2","unstructured":"ICI\/UCEDD.Residential services for persons with developmental disabilities: status and trends through 2006. Research and Training Center on Community Living University of Minnesota.2007. Available athttp:\/\/rtc.umn.edu\/docs\/risp2006.pdf"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1177\/070674379704200505"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1352\/0047-6765(2001)039<0130:ECITCO>2.0.CO;2"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2002.tb00268.x"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2007.00654.x"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1009924810229"},{"key":"e_1_2_7_28_2","first-page":"41","article-title":"Combined treatment with BTX\u2010A and ITB for spasticity: case report","volume":"100","author":"Gill CE","year":"2007","journal-title":"Tenn Med"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2006.tb01309.x"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2006.08.343"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2007.00086.x"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001888-200504000-00009"},{"key":"e_1_2_7_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccm.2007.02.007"},{"key":"e_1_2_7_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.1154"},{"key":"e_1_2_7_35_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.113.3.e197"},{"key":"e_1_2_7_36_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2004.tb00454.x"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.22995","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.22995","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.22995","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:20:52Z","timestamp":1760955652000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.22995"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,3,15]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2010,3,15]]}},"alternative-id":["10.1002\/mds.22995"],"URL":"https:\/\/doi.org\/10.1002\/mds.22995","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"value":"0885-3185","type":"print"},{"value":"1531-8257","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,3,15]]}}}