{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T11:47:24Z","timestamp":1791028044490,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2010,2,3]],"date-time":"2010-02-03T00:00:00Z","timestamp":1265155200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2010,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Approximately 10% of patients diagnosed clinically with early Parkinson's disease (PD) have normal dopaminergic functional imaging (Scans Without Evidence of Dopaminergic Deficit [SWEDDs]). An important subgroup of SWEDDs are those with asymmetric rest tremor resembling parkinsonian tremor. Clinical and pathophysiological features which could help to distinguish SWEDDs from PD have not been explored. We therefore studied clinical details including non\u2010motor symptoms in 25 tremulous SWEDDs patients in comparison to 25 tremor\u2010dominant PD patients. Blinded video rating was used to compare examination findings. Electrophysiological tremor parameters and also response to a cortical plasticity protocol using paired associative stimulation (PAS) was studied in 9 patients with SWEDDs, 9 with tremor\u2010dominant PD (with abnormal dopamine transporter single photon emission computed tomography findings), 8 with segmental dystonia, and 8 with essential tremor (ET). Despite clinical overlap, lack of true bradykinesia, presence of dystonia, and head tremor favored a diagnosis of SWEDDs, whereas re\u2010emergent tremor, true fatiguing or decrement, good response to dopaminergic drugs, and presence of non\u2010motor symptoms favored PD. A single tremor parameter could not differentiate between groups, but the combination of re\u2010emergent tremor and highest tremor amplitude at rest was characteristic of PD tremor. SWEDDs and segmental dystonia patients exhibited an abnormal exaggerated response to the PAS protocol, in contrast to a subnormal response in PD and a normal response in ET. We conclude that despite clinical overlap, there are features that can help to distinguish between PD and SWEDDs which may be useful in clinical practice. The underlying pathophysiology of SWEDDs differs from PD but has similarities with primary dystonia. \u00a9 2010 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.23019","type":"journal-article","created":{"date-parts":[[2010,2,3]],"date-time":"2010-02-03T16:55:30Z","timestamp":1265216130000},"page":"560-569","source":"Crossref","is-referenced-by-count":214,"title":["Distinguishing SWEDDs patients with asymmetric resting tremor from Parkinson's disease: A clinical and electrophysiological study"],"prefix":"10.1002","volume":"25","author":[{"given":"Petra","family":"Schwingenschuh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane","family":"Ruge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark J.","family":"Edwards","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Terranova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Katschnig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatima","family":"Carrillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Silveira\u2010Moriyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne A","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"K\u00e4gi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco J","family":"Palomar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Penelope","family":"Talelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Dickson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Lees","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niall","family":"Quinn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Mir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C.","family":"Rothwell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kailash P.","family":"Bhatia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,4,21]]},"reference":[{"issue":"1","key":"e_1_2_8_2_2","first-page":"A293","article-title":"Beta\u2010CIT scans without evidemce of dopaminergic deficit (SWEDD) in the ELLDOPA\u2010CIT and CALM\u2010cit study: long\u2010term imaging assessment","volume":"60","author":"Marek K","year":"2003","journal-title":"Neurology"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10609"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-005-4008-5"},{"issue":"1","key":"e_1_2_8_5_2","first-page":"A274","article-title":"Long\u2010term follow\u2010up of patients with scans without evidence of dopaminergic deficit (SWEDD) in the ELLDOPA study","volume":"64","author":"Marek K","year":"2005","journal-title":"Neurology"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21685"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181a18809"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2009.172825"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/123.3.572"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00900.2002"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2005.084954"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awg273"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2007.121632"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl221"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl031"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20692"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.40.10.1529"},{"issue":"3","key":"e_1_2_8_18_2","first-page":"2","article-title":"Consensus statement of the Movement Disorder Society on Tremor. 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