{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T16:56:23Z","timestamp":1776531383433,"version":"3.51.2"},"reference-count":68,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2010,5,14]],"date-time":"2010-05-14T00:00:00Z","timestamp":1273795200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2010,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The combination of recessive early\u2010onset parkinsonism and pyramidal tract signs caused by pallidopyramidal degeneration is known as pallidopyramidal disease or syndrome (PPD\/S). We investigated whether patients diagnosed as Davison's PPD\/S showed any definite proof of pyramidal and pallidal involvement, without findings suggestive of other nosological entities. Since Davison's original description, 15 other PPD\/S cases have been reported, yet all lack proof of pyramidal or pallidal degeneration. Because of the dopa\u2010responsiveness in all patients subsequent to Davison's report, we argue that these patients probably suffered from early\u2010onset nigral parkinsonism or dopa\u2010responsive dsystonia, rather than pallidal parkinsonism; in such cases, the presumed pyramidal Babinski could be a pseudobabinski (\u201cstriatal toe\u201d). Secondary pallidopyramidal syndromes do occur, for example, in multiple system atrophy or Wilson's disease, but in these patients additional findings indicate diseases other than Davison's PPD\/S. We conclude that the existence of PPD\/S as a distinct clinico\u2010pathological nosological entity, as proposed by Davison, is doubtful. In cases reported as Davison's PPD\/S, the description \u201cpallidopyramidal\u201d seems to be a misnomer. \u00a9 2010 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.23118","type":"journal-article","created":{"date-parts":[[2010,5,14]],"date-time":"2010-05-14T12:42:06Z","timestamp":1273840926000},"page":"1109-1115","source":"Crossref","is-referenced-by-count":8,"title":["Pallidopyramidal disease: A misnomer?"],"prefix":"10.1002","volume":"25","author":[{"given":"Martin W.I.M.","family":"Horstink","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marieke 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