{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T05:51:50Z","timestamp":1770011510166,"version":"3.49.0"},"reference-count":56,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2010,8,3]],"date-time":"2010-08-03T00:00:00Z","timestamp":1280793600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2010,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Patients with Gilles de la Tourette syndrome (GTS) can display socially inappropriate behaviors as part of their multiform tic phenomenology. Pathological laughter (PL), defined as the presence of episodic and contextually inappropriate outbursts of laughter, has been detailed as a symptom of various psychiatric and neurological conditions. We present a case series of eight subjects diagnosed with GTS who reported PL as part of their tic repertoire. All subjects experienced PL as a simple phonic tic, accompanied by characteristic premonitory urges and significant impairment in social interactions. In addition, all patients presented with multiple tic\u2010related symptoms (mainly self\u2010injurious behaviors and echolalia, n = 7; palilalia, n = 6; coprolalia\/mental coprolalia, n = 5), and six patients had comorbid conditions (in particular obsessive\u2010compulsive disorder\/behaviors, n = 7; attention\u2010deficit hyperactivity disorder, n = 4). We suggest that the pathophysiological mechanisms underlying the expression of PL as a tic could involve a dissociation between frontostriatal and limbic networks. \u00a9 2010 Movement Disorder Society.<\/jats:p>","DOI":"10.1002\/mds.23216","type":"journal-article","created":{"date-parts":[[2010,8,3]],"date-time":"2010-08-03T10:05:13Z","timestamp":1280829913000},"page":"2233-2239","source":"Crossref","is-referenced-by-count":21,"title":["Pathological laughter in Gilles de la Tourette syndrome: An unusual phonic tic"],"prefix":"10.1002","volume":"25","author":[{"given":"Andrea E.","family":"Cavanna","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fizzah","family":"Ali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James F.","family":"Leckman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary 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