{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:05:41Z","timestamp":1792782341744,"version":"4.5.0"},"reference-count":38,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2010,7,9]],"date-time":"2010-07-09T00:00:00Z","timestamp":1278633600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007197","name":"USPHS","doi-asserted-by":"crossref","award":["DA15408"],"award-info":[{"award-number":["DA15408"]}],"id":[{"id":"10.13039\/100007197","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100007197","name":"USPHS","doi-asserted-by":"crossref","award":["MH57440 (AAG)"],"award-info":[{"award-number":["MH57440 (AAG)"]}],"id":[{"id":"10.13039\/100007197","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Young Investigator Award from NARSAD-The Mental Health Research Association"},{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche Medicale","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2010,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Chronic levodopa treatment for Parkinson's disease often results in the development of abnormal involuntary movement, known as\n                    <jats:sc>L<\/jats:sc>\n                    \u2010dopa\u2010induced dyskinesia (LIDs). Studies suggest that LIDs may be associated with aberrant corticostriatal plasticity. Using\n                    <jats:italic>in vivo<\/jats:italic>\n                    extracellular recordings from identified Type I and Type II medium spiny striatal neurons, chronic\n                    <jats:sc>L<\/jats:sc>\n                    \u2010dopa treatment was found to produce abnormal corticostriatal information processing. Specifically, after chronic\n                    <jats:sc>L<\/jats:sc>\n                    \u2010dopa treatment in dopamine\u2010depleted rats, there was a transition from a cortically evoked long\u2010term depression (LTD) to a complementary but opposing form of plasticity, long\u2010term potentiation, in Type II \u201cindirect\u201d pathway neurons. In contrast, LTD could still be induced in Type I neurons. Interestingly, the one parameter that correlated best with dyskinesias was the inability to de\u2010depress established LTD in Type I medium spiny striatal neurons. Taken as a whole, we propose that the induction of LIDs is due, at least in part, to an aberrant induction of plasticity within the Type II indirect pathway neurons combined with an inability to de\u2010depress established plastic responses in Type I neurons. Such information is critical for understanding the cellular mechanisms underlying one of the major caveats to\n                    <jats:sc>L<\/jats:sc>\n                    \u2010dopa therapy. \u00a9 2010 Movement Disorder Society\n                  <\/jats:p>","DOI":"10.1002\/mds.23245","type":"journal-article","created":{"date-parts":[[2010,7,12]],"date-time":"2010-07-12T00:44:31Z","timestamp":1278895471000},"page":"1568-1576","source":"Crossref","is-referenced-by-count":53,"title":["Aberrant striatal plasticity is specifically associated with dyskinesia following levodopa treatment"],"prefix":"10.1002","volume":"25","author":[{"given":"Pauline","family":"Belujon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"Lodge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony 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