{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T04:44:37Z","timestamp":1770353077293,"version":"3.49.0"},"reference-count":25,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2010,7,28]],"date-time":"2010-07-28T00:00:00Z","timestamp":1280275200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2010,10,30]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of this article is to test the feasibility, in early Parkinson's disease (PD), of an overnight switch from immediate\u2010release (IR) pramipexole to a new once\u2010daily extended\u2010release (ER) formulation. Nonfluctuating patients on pramipexole IR three\u2010times daily, alone or with levodopa, for early PD were randomly switched overnight to double\u2010blind IR three\u2010times daily (N = 52) or ER once\u2010daily (N = 104) at initially unchanged daily dosage. Successful switching (defined as no worsening &gt;15% of baseline UPDRS II+III score and no drug\u2010related adverse event withdrawal) was assessed at 9 weeks, after optional dosage adjustments (primary endpoint), and at 4 weeks, before adjustment. Other secondary endpoints included adjusted mean changes from baseline in UPDRS scores and proportion of responders based on Clinical or Patient Global Impression (CGI\/PGI). Absolute difference between percentage of successful switch to ER versus IR was tested for ER noninferiority, defined as a 95% confidence\u2010interval lower bound not exceeding \u221215%. At 9 weeks, 84.5% of the ER group had been successfully switched, versus 94.2% for IR. Noninferiority was not demonstrated, with a difference of \u22129.76% (95% CI: [\u221218.81%, +1.66%]). At 4 weeks, 81.6% of the ER group had been successfully switched, versus 92.3% for IR, a difference of \u221210.75% (95% CI: [\u221220.51%, +1.48%]). UPDRS changes and CGI\/PGI analyses showed no differences between the groups. Both formulations were safe and well tolerated. Pramipexole ER was not equivalent to IR, but the difference was marginal. The fact that &gt;80% of the patients successfully switched overnight at unchanged dosage shows that this practice was feasible in most patients. \u00a9 2010 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.23262","type":"journal-article","created":{"date-parts":[[2010,7,28]],"date-time":"2010-07-28T16:24:21Z","timestamp":1280334261000},"page":"2326-2332","source":"Crossref","is-referenced-by-count":30,"title":["Efficacy, safety, and tolerability of overnight switching from immediate\u2010 to once daily extended\u2010release pramipexole in early Parkinson's disease"],"prefix":"10.1002","volume":"25","author":[{"given":"Olivier","family":"Rascol","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Barone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert 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