{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T19:29:55Z","timestamp":1792092595131,"version":"4.4.0"},"reference-count":38,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2010,8,24]],"date-time":"2010-08-24T00:00:00Z","timestamp":1282608000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2010,10,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Based on several open\u2010label and case studies, repetitive transcranial magnetic stimulation (rTMS) seems to have an antidepressive effect on patients with Parkinson's disease (PD). However, this hypothesis requires further confirmation. We conducted a randomized, double\u2010blind placebo\u2010controlled study to evaluate the effect of rTMS over the left dorsolateral prefrontal cortex (DLPFC) on depression and various motor and nonmotor features of PD. Twenty\u2010two PD patients with mild or moderate depressive episodes were assigned into two groups, one receiving real\u2010rTMS (90% of resting motor threshold, 5 Hz, 600 pulses\u2010a\u2010day for 10 days) over the left DLPFC, and another group receiving sham\u2010rTMS. An investigator blinded to the treatment performed three video\u2010taped examinations on each patient: before stimulation (baseline), 1 day (short term), and 30 days after treatment session ended (long\u2010term effect). Mini\u2010Mental State Examination, Unified Parkinson's Disease Rating Scale (UPDRS), Hoehn\u2010Yahr, Epworth Sleepiness, Visual Analog and Montgomery\u2010Asberg Depression Rating Scales (MADRS), Beck Depression Inventory (BDI), and Trail making and Stroop tests were applied. In the actively treated group, not only depression rating scales showed significant improvement 30 days after treatment ended (BDI by 44.4% and MADRS by 26.1%), but also the accuracy of Stroop test (by 16%). We could also demonstrate an insignificant improvement in UPDRS\u2010III by 7.5 points (31.9%,\n                    <jats:italic>P<\/jats:italic>\n                    = 0.06). In the sham\u2010treated group none of the examined tests and scales improved significantly after sham stimulation. Our study demonstrated the beneficial effect of the left DLPFC rTMS on depression in PD lasting at least 30 days after treatment. However, this result should be confirmed in patients with severe depression by further clinical trials. \u00a9 2010 Movement Disorder Society\n                  <\/jats:p>","DOI":"10.1002\/mds.23270","type":"journal-article","created":{"date-parts":[[2010,8,29]],"date-time":"2010-08-29T14:44:49Z","timestamp":1283093089000},"page":"2311-2317","source":"Crossref","is-referenced-by-count":185,"title":["The impact of left prefrontal repetitive transcranial magnetic stimulation on depression in Parkinson's disease: A randomized, double\u2010blind, placebo\u2010controlled 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