{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T01:51:48Z","timestamp":1789177908749,"version":"build-2803163510"},"reference-count":41,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2010,8,18]],"date-time":"2010-08-18T00:00:00Z","timestamp":1282089600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2010,10,30]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Freezing of gait (FOG) is one of the most disabling symptoms that affect patients with Parkinson's disease (PD). Although the pathophysiology underlying FOG largely remains an enigma, several lines of evidence suggest that the autonomic nervous system might be involved. To this end, we tested the hypothesis that heart rate (HR) increases during FOG and, further, that HR increases just before FOG. To evaluate these hypotheses, 15 healthy older adults, 10 patients with PD who experienced FOG, and 10 patients who did not were studied. Patients with PD were tested during their \u201coff\u201d medication state. HR and HR variability were measured as subjects carried out tasks that frequently provoke FOG; 120 FOG episodes were evaluated. During FOG, HR increased (<jats:italic>P<\/jats:italic> = 0.001) by an average of 1.8 bpm, compared with HR measured before the beginning of FOG. HR also increased just before FOG, by 1 bpm (<jats:italic>P<\/jats:italic> &lt; 0.0001). In contrast, during sudden stops and 180\u00b0 turns, HR decreased by almost 2 bpm (<jats:italic>P<\/jats:italic> &lt; 0.0001). HR variability was not associated with FOG. To our knowledge, these findings are the first to document the association of FOG to autonomic system activation, as manifested by HR dynamics. One explanation is that the changes in HR before and during FOG may be a sympathetic response that, secondary to limbic activation, contributes to the development of freezing. Although further studies are needed to evaluate these associations, the current results provide experimental evidence linking impaired motor blockades to autonomic nervous system function among patients with PD. \u00a9 2010 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.23280","type":"journal-article","created":{"date-parts":[[2010,8,18]],"date-time":"2010-08-18T23:00:50Z","timestamp":1282172450000},"page":"2346-2354","source":"Crossref","is-referenced-by-count":60,"title":["Heart rate changes during freezing of gait in patients with Parkinson's 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