{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T05:32:42Z","timestamp":1761975162169,"version":"build-2065373602"},"reference-count":17,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2010,9,3]],"date-time":"2010-09-03T00:00:00Z","timestamp":1283472000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"\u201cInnovative Medical Research\u201d of the University of M\u00fcnster Medical School","award":["# RE 12 02 25"],"award-info":[{"award-number":["# RE 12 02 25"]}]},{"name":"Department of Radiology, Max Planck Institute of Psychiatry, Munich"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2010,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Future clinical trials in subjects with premanifest Huntington's disease (preHD) may depend on the availability of biomarkers. It was previously shown in symptomatic HD that, the grip force variability coefficient\u2010of\u2010variation (GFV\u2010C) in a grasping paradigm was correlated to the Unified\u2010Huntington's\u2010Disease\u2010Rating\u2010Scale\u2010Total\u2010Motor\u2010Score (UHDRS\u2010TMS) and increased in a 3 year follow\u2010up study. To further elucidate its potential as a biomarker, we investigated whether GFV\u2010C is able to detect a motor phenotype in preHD and is correlated to the genotype assessed by a disease\u2010burden\u2010score. The ability of preHD (n = 15) and symptomatic HD subjects (n = 20) to maintain stable grip forces, while holding an object (250 g and 500 g), was measured and compared with the controls (n = 19). GFV\u2010C was increased in preHD at 500 g, in symptomatic subjects at both weights and was correlated to the disease\u2010burden\u2010score and UHDRS\u2010TMS. GFV\u2010C may be a useful objective and quantitative marker of motor dysfunction across genetically diagnosed premanifest and symptomatic HD subjects. \u00a9 2010 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.23300","type":"journal-article","created":{"date-parts":[[2010,9,5]],"date-time":"2010-09-05T02:48:36Z","timestamp":1283654916000},"page":"2858-2862","source":"Crossref","is-referenced-by-count":36,"title":["Grasping premanifest Huntington's disease \u2013 shaping new endpoints for new trials"],"prefix":"10.1002","volume":"25","author":[{"given":"Ralf","family":"Reilmann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Bohlen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Klopstock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Bender","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adolf","family":"Weindl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philipp","family":"Saemann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorothee P.","family":"Auer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erich B.","family":"Ringelstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herwig W.","family":"Lange","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,9,3]]},"reference":[{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90585-E"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.8.2.141"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2007.128728"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60111-1"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870110204"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.65.12.1582"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/1-4020-2898-9_26"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1996.00550060029011"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/35000576"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.2000.7348"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.57.5.920"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21987"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20482"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410410521"},{"key":"e_1_2_9_16_2","first-page":"179.","article-title":"Modified mini\u2010mental state examination: validity and reliability","volume":"37","author":"Stern Y","year":"1987","journal-title":"Neurology"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20332"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0308679101"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.23300","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.23300","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.23300","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T09:27:19Z","timestamp":1760952439000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.23300"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,9,3]]},"references-count":17,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2010,12,15]]}},"alternative-id":["10.1002\/mds.23300"],"URL":"https:\/\/doi.org\/10.1002\/mds.23300","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"type":"print","value":"0885-3185"},{"type":"electronic","value":"1531-8257"}],"subject":[],"published":{"date-parts":[[2010,9,3]]}}}