{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T13:13:06Z","timestamp":1791033186626,"version":"4.1.0"},"reference-count":59,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2010,7,8]],"date-time":"2010-07-08T00:00:00Z","timestamp":1278547200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2010,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Deep brain stimulation (DBS) of the internal globus pallidus (GPi) and ventral intermediate thalamic nucleus (VIM) are established treatment options in primary dystonia and tremor syndromes and have been reported anecdotally to be efficacious in myoclonus\u2010dystonia (MD). We investigated short\u2010 and long\u2010term effects on motor function, cognition, affective state, and quality of life (QoL) of GPi\u2010 and VIM\u2010DBS in MD. Ten MD\u2010patients (nine \u03b5\u2010sarcoglycan\u2010mutation\u2010positive) were evaluated pre\u2010 and post\u2010surgically following continuous bilateral GPi\u2010 and VIM\u2010DBS at four time points: presurgical, 6, 12, and as a last follow\u2010up at a mean of 62.3 months postsurgically, and in OFF\u2010, GPi\u2010, VIM\u2010, and GPi\u2010VIM\u2010DBS conditions by validated motor [unified myoclonus rating scale (UMRS), TSUI Score, Burke\u2010Fahn\u2010Marsden dystonia rating scale (BFMDRS)], cognitive, affective, and QoL\u2010scores. MD\u2010symptoms significantly improved at 6 months post\u2010surgery (UMRS: 61.5%, TSUI Score: 36.5%, BFMDRS: 47.3%). Beneficial effects were sustained at long\u2010term evaluation post\u2010surgery (UMRS: 65.5%, TSUI Score: 35.1%, BFMDRS: 48.2%). QoL was significantly ameliorated; affective status and cognition remained unchanged postsurgically irrespective of the stimulation conditions. No serious long\u2010lasting stimulation\u2010related adverse events (AEs) were observed. Both GPi\u2010 and VIM\u2010DBS offer equally effective and safe treatment options for MD. With respect to fewer adverse, stimulation\u2010induced events of GPi\u2010DBS in comparison with VIM\u2010DBS, GPi\u2010DBS seems to be preferable. Combined GPi\u2010VIM\u2010DBS can be useful in cases of incapaciting myoclonus, refractory to GPi\u2010DBS alone. \u00a9 2010 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.23312","type":"journal-article","created":{"date-parts":[[2010,7,8]],"date-time":"2010-07-08T15:09:50Z","timestamp":1278601790000},"page":"1733-1743","source":"Crossref","is-referenced-by-count":122,"title":["Pallidal and thalamic deep brain stimulation in myoclonus\u2010dystonia"],"prefix":"10.1002","volume":"25","author":[{"given":"Doreen","family":"Gruber","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea A.","family":"K\u00fchn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Schoenecker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anatol","family":"Kivi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Trottenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl\u2010Titus","family":"Hoffmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alireza","family":"Gharabaghi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ute A.","family":"Kopp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerd\u2010Helge","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Klein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friedrich","family":"Asmus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Kupsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,8,18]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21715"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2008.162099"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22425"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000188670.38576.bd"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.54.8.1706"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa063618"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(07)70035-2"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa042187"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2009.20"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.66.3.289"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2003.09.002"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200002173420703"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22551"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2004.039248"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.3171\/2009.10.JNS091062"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2008.10.015"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.67.3.415"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.1119"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2004.057992"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000216131.41563.24"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10325"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/humu.9521"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21481"},{"key":"e_1_2_6_25_2","volume-title":"Neuropsychological assessment.","author":"Lezak M","year":"1995"},{"key":"e_1_2_6_26_2","first-page":"189","article-title":"Mini\u2010mental state\u201d. 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