{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T07:50:10Z","timestamp":1778053810006,"version":"3.51.4"},"reference-count":55,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2010,12,13]],"date-time":"2010-12-13T00:00:00Z","timestamp":1292198400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"NIH","award":["2R01ES10751"],"award-info":[{"award-number":["2R01ES10751"]}]},{"name":"Mayo's Molecular Epidemiology of Parkinson's Disease research team"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2011,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Rare mutations in PARK loci genes cause Parkinson's disease (PD) in some families and isolated populations. We investigated the association of common variants in PARK loci and related genes with PD susceptibility and age at onset in an outbred population. A total of 1,103 PD cases from the upper Midwest, USA, were individually matched to unaffected siblings (n = 654) or unrelated controls (n = 449) from the same region. Using a sequencing approach in 25 cases and 25 controls, single nucleotide polymorphisms (SNPs) in species\u2010conserved regions of PARK loci and related genes were detected. We selected additional tag SNPs from the HapMap. We genotyped a total of 235 SNPs and two variable number tandem repeats in the <jats:italic>ATP13A2<\/jats:italic>, <jats:italic>DJ1<\/jats:italic>, <jats:italic>LRRK1<\/jats:italic>, <jats:italic>LRRK2<\/jats:italic>, <jats:italic>MAPT<\/jats:italic>, <jats:italic>Omi<\/jats:italic>\/<jats:italic>HtrA2<\/jats:italic>, <jats:italic>PARK2<\/jats:italic>, <jats:italic>PINK1<\/jats:italic>, <jats:italic>SNCA<\/jats:italic>, <jats:italic>SNCB<\/jats:italic>, <jats:italic>SNCG<\/jats:italic>, <jats:italic>SPR<\/jats:italic>, and <jats:italic>UCHL1<\/jats:italic> genes in all 2,206 subjects. Case\u2010control analyses were performed to study association with PD susceptibility, while cases\u2010only analyses were used to study association with age at onset. Only <jats:italic>MAPT<\/jats:italic> SNP rs2435200 was associated with PD susceptibility after correction for multiple testing (OR = 0.74, 95% CI = 0.64\u20130.86, uncorrected <jats:italic>P<\/jats:italic> &lt; 0.0001, log additive model); however, 16 additional <jats:italic>MAPT<\/jats:italic> variants, seven <jats:italic>SNCA<\/jats:italic> variants, and one <jats:italic>LRRK2<\/jats:italic>, <jats:italic>PARK2<\/jats:italic>, and <jats:italic>UCHL1<\/jats:italic> variants each had significant uncorrected <jats:italic>P<\/jats:italic>\u2010values. There were no significant associations for age at onset after correction for multiple testing. Our results confirm the association of <jats:italic>MAPT<\/jats:italic> and <jats:italic>SNCA<\/jats:italic> genes with PD susceptibility but show limited association of other PARK loci and related genes with PD. \u00a9 2010 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.23376","type":"journal-article","created":{"date-parts":[[2010,12,14]],"date-time":"2010-12-14T09:27:39Z","timestamp":1292318859000},"page":"280-288","source":"Crossref","is-referenced-by-count":33,"title":["Common variants in PARK loci and related genes and Parkinson's disease"],"prefix":"10.1002","volume":"26","author":[{"given":"Sun Ju","family":"Chung","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian M.","family":"Armasu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna M.","family":"Biernacka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy G.","family":"Lesnick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David N.","family":"Rider","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah J.","family":"Lincoln","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra I.","family":"Ortolaza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew J.","family":"Farrer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie M.","family":"Cunningham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walter A.","family":"Rocca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Demetrius M.","family":"Maraganore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,12,13]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(01)00425-5"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.276.5321.2045"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.67"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/33416"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/26652"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1096284"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1077209"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2004.10.023"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2004.11.005"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1884"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2008.01.015"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddi215"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20017"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.296.6.661"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1086\/496902"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2005.02.008"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000304049.31377.f2"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000152585.76852.9C"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(98)00017-1"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a113955"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a116946"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2008.11.011"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature04226"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddn340"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000346517.98982.1b"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bth457"},{"key":"e_1_2_7_28_2","first-page":"5","article-title":"Statistical methods in cancer research. 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