{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T09:03:48Z","timestamp":1787907828779,"version":"build-2784847793"},"reference-count":37,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2010,10,4]],"date-time":"2010-10-04T00:00:00Z","timestamp":1286150400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"NIH","award":["NCRR UL1RR024992"],"award-info":[{"award-number":["NCRR UL1RR024992"]}]},{"name":"NIH","award":["NINDS P30NS05710"],"award-info":[{"award-number":["NINDS P30NS05710"]}]},{"name":"Neuroscience Blueprint Grant"},{"name":"American Parkinson Disease Association (APDA)"},{"name":"Advanced Research Center for Parkinson Disease at Washington University"},{"DOI":"10.13039\/100007338","name":"Barnes-Jewish Hospital Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007338","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Elliot H. Stein Family Fund"},{"name":"Handelman Fund"},{"name":"Jack Buck Fund"},{"name":"Alzheimer's Disease Research Center at Washington University School of Medicine"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2010,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Clinicopathologic studies of Parkinson disease dementia (PDD) and dementia with Lewy bodies (DLB) commonly reveal abnormal \u03b2\u2010amyloid deposition in addition to diffuse Lewy bodies (\u03b1\u2010synuclein aggregates), but the relationship among these neuropathologic features and the development of dementia in these disorders remains uncertain. The purpose of this study was to determine whether amyloid\u2010\u03b2 deposition detected by PET imaging with Pittsburgh Compound B (PIB) distinguishes clinical subtypes of Lewy body\u2010associated disorders. Nine healthy controls, 8 PD with no cognitive impairment, 9 PD with mild cognitive impairment, 6 DLB, and 15 PDD patients underwent [<jats:sup>11<\/jats:sup>C]\u2010PIB positron emission tomography imaging, clinical examination, and cognitive testing. The binding potential (BP) of PIB for predefined regions and the mean cortical BP (MCBP) were calculated for each participant. Annual longitudinal follow\u2010up and postmortem examinations were performed on a subset of participants. Regional PIB BPs and the proportion of individuals with abnormally elevated MCBP were not significantly different across participant groups. Elevated PIB binding was associated with worse global cognitive impairment in participants with Lewy body disorders but was not associated with any other clinical or neuropsychological features, including earlier onset or faster rate of progression of cognitive impairment. These results suggest that the presence of fibrillar amyloid\u2010\u03b2 does not distinguish between clinical subtypes of Lewy body\u2010associated disorders, although larger numbers are needed to more definitively rule out this association. Amyloid\u2010\u03b2 may modify the severity of global cognitive impairment in individuals with Lewy body\u2010associated dementia. \u00a9 2010 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.23393","type":"journal-article","created":{"date-parts":[[2010,10,4]],"date-time":"2010-10-04T16:55:54Z","timestamp":1286211354000},"page":"2516-2523","source":"Crossref","is-referenced-by-count":134,"title":["Amyloid imaging of Lewy body\u2010associated disorders"],"prefix":"10.1002","volume":"25","author":[{"given":"Erin R.","family":"Foster","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meghan C.","family":"Campbell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle 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