{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T15:04:20Z","timestamp":1773155060589,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2010,10,19]],"date-time":"2010-10-19T00:00:00Z","timestamp":1287446400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2011,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Since a postinfectious or autoimmune etiology is suggested to be involved in the pathogenesis of Tourette's syndrome (TS), we investigated oligoclonal bands (OB) of immunoglobulin G (IgG) in cerebrospinal fluid (CSF), indicating a humoral immune response in the central nervous system. CSF examinations including isoelectric focusing to analyze the presence of OB were performed in 21 TS patients [17 men\/4 women, mean age = 29 \u00b1 12 (SD) years]. Isoelectric focusing showed the presence of positive OB in 6, borderline bands in 2, and serum and CSF bands (\u201cmirrored pattern\u201d) in another 2 patients. Clinical data did not correlate with CSF findings. Thus, 38% (8 of 21) of our patients exhibited pathological CSF bands. Since none of them suffered from another disease known to be associated with OB, our results suggest an association with the pathogenesis of TS itself and point to an involvement of immunological mechanisms in TS pathology. \u00a9 2010 Movement Disorder Society.<\/jats:p>","DOI":"10.1002\/mds.23403","type":"journal-article","created":{"date-parts":[[2010,10,19]],"date-time":"2010-10-19T14:14:23Z","timestamp":1287497663000},"page":"343-346","source":"Crossref","is-referenced-by-count":23,"title":["Oligoclonal bands in cerebrospinal fluid in patients with Tourette's syndrome"],"prefix":"10.1002","volume":"26","author":[{"given":"Claudia","family":"Wenzel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrich","family":"Wurster","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirsten R.","family":"M\u00fcller\u2010Vahl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,10,19]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)11526-1"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-003-3320-4"},{"key":"e_1_2_6_4_2","first-page":"I\/24","article-title":"Association of common cold with exacerbations in tic disorder patients: a prospective longitudinal study","volume":"12","author":"Hoekstra PJ","year":"2004","journal-title":"Eur Child Adolesc Psychiatry"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.155.2.264"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/chi.0b013e318068fbcc"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181bd10fd"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181beed27"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-1781(00)00125-6"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-2658"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2009.06.015"},{"key":"e_1_2_6_12_2","first-page":"208","volume-title":"Hrsg. Klinische Liquordiagnostik","author":"Wurster U","year":"2005"},{"key":"e_1_2_6_13_2","first-page":"127","volume-title":"Gilles de la Tourette syndrome","author":"Shapiro AK","year":"1988"},{"key":"e_1_2_6_14_2","first-page":"115","article-title":"Isoelectric focusing on macro polyamide gels with automated silver staining: a versatile method for demonstration of oligoclonal bands in the CSF by direct protein stain or IgG immunofixation, and the identification of beta\u20102\u2010transferrin in CSF rhinorrhoea","volume":"49","author":"Wurster U","year":"2003","journal-title":"Clin Chem"},{"key":"e_1_2_6_15_2","first-page":"S62","article-title":"Reference values for standard cerebrospinal fluid examinations in multiple sclerosis: results from 99 healthy volunteers","volume":"12","author":"Wurster U","year":"2006","journal-title":"Mult Scler"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5728(03)00012-2"},{"key":"e_1_2_6_17_2","unstructured":"KiesslingLS AbbottLR BensonMD.Evidence of striatal autoimmunity in cerebrospinal fluid in a child with a movement disorder. Poster abstracts 3rd International Scientific Symposium on Tourette's Syndrome June 4\u20136 1999 New York City (Abstract)."}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.23403","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.23403","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T11:59:41Z","timestamp":1760961581000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.23403"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10,19]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,2]]}},"alternative-id":["10.1002\/mds.23403"],"URL":"https:\/\/doi.org\/10.1002\/mds.23403","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"value":"0885-3185","type":"print"},{"value":"1531-8257","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,10,19]]}}}