{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T19:12:24Z","timestamp":1792005144600,"version":"4.4.0"},"reference-count":36,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2010,10,19]],"date-time":"2010-10-19T00:00:00Z","timestamp":1287446400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2010,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The purpose of the current study was to examine changes in dopamine D2 receptor (DA\u2010D2R) expression within the basal ganglia of MPTP mice subjected to intensive treadmill exercise. Using Western immunoblotting analysis of synaptoneurosomes and\n                    <jats:italic>in vivo<\/jats:italic>\n                    positron emission tomography (PET) imaging employing the DA\u2010D2R specific ligand [\n                    <jats:sup>18<\/jats:sup>\n                    F]fallypride, we found that high intensity treadmill exercise led to an increase in striatal DA\u2010D2R expression that was most pronounced in MPTP compared to saline treated mice. Exercise\u2010induced changes in the DA\u2010D2R in the dopamine\u2010depleted basal ganglia are consistent with the potential role of this receptor in modulating medium spiny neurons (MSNs) function and behavioral recovery. Importantly, findings from this study support the rationale for using PET imaging with [\n                    <jats:sup>18<\/jats:sup>\n                    F]fallypride to examine DA\u2010D2R changes in individuals with Parkinson's Disease (PD) undergoing high\u2010intensity treadmill training. \u00a9 2010 Movement Disorder Society.\n                  <\/jats:p>","DOI":"10.1002\/mds.23407","type":"journal-article","created":{"date-parts":[[2010,10,19]],"date-time":"2010-10-19T14:14:23Z","timestamp":1287497663000},"page":"2777-2784","source":"Crossref","is-referenced-by-count":156,"title":["Exercise elevates dopamine D2 receptor in a mouse model of Parkinson's disease: In vivo imaging with [\n                    <sup>18<\/sup>\n                    F]fallypride"],"prefix":"10.1002","volume":"25","author":[{"given":"Marta G.","family":"Vu\u010dckovi\u0107","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quanzheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beth","family":"Fisher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"Nacca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard M.","family":"Leahy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John P.","family":"Walsh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jogesh","family":"Mukherjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celia","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael W.","family":"Jakowec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giselle M.","family":"Petzinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,10,19]]},"reference":[{"key":"e_1_2_7_2_2","first-page":"16","article-title":"Aerobic exercise intervention improves aerobic capacity and movement initiation in Parkinson's disease patients","volume":"17","author":"Bergen JL","year":"2002","journal-title":"NeuroRehabilitation"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.44.3_Part_1.376"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.2522\/ptj.20060351"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2202-10-6"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.20162"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1069-07.2007"},{"key":"e_1_2_7_8_2","first-page":"1352","article-title":"PET studies of the effects of aerobic exercise on human striatal dopamine release","volume":"41","author":"Wang GJ","year":"2000","journal-title":"J Nucl Med"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2396(199704)25:4<321::AID-SYN2>3.0.CO;2-C"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0893-133X(01)00251-2"},{"key":"e_1_2_7_11_2","first-page":"464","article-title":"Dynamic imaging of striatal D2 receptors in mice using quad\u2010HIDAC PET","volume":"45","author":"Honer M","year":"2004","journal-title":"J Nucl Med"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(88)90575-7"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0969-8051(99)00012-8"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/1098-2396(200010)38:1<71::AID-SYN8>3.0.CO;2-2"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/43\/4\/027"},{"key":"e_1_2_7_16_2","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1097\/01.WCB.0000038000.34930.4E","article-title":"Strategies to improve neuroreceptor parameter estimation by linear regression analysis","volume":"22","author":"Ichise M","year":"2002","journal-title":"J Cereb Blood Flow Metab"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-199609000-00008"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1118\/1.598130"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410150302"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.1996.0066"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-328X(00)00194-7"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0270(97)00120-9"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/227680a0"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1080\/02701367.1991.10608733"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/syn.20506"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2005.12.001"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22027"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.20.9576"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16-18-05870.1996"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1997.78.3.1248"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn1632"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.22216"},{"key":"e_1_2_7_33_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0953-816X.2004.03344.x"},{"key":"e_1_2_7_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2007.03.008"},{"issue":"2","key":"e_1_2_7_35_2","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1093\/brain\/116.2.433","article-title":"Electrophysiology of dopamine\u2010denervated striatal neurons. Implications for Parkinson's disease","volume":"116","author":"Calabresi P","year":"1993","journal-title":"Brain"},{"key":"e_1_2_7_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2009.05.019"},{"key":"e_1_2_7_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-7634(96)00029-2"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.23407","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.23407","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.23407","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T09:27:12Z","timestamp":1760952432000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.23407"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10,19]]},"references-count":36,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2010,12,15]]}},"alternative-id":["10.1002\/mds.23407"],"URL":"https:\/\/doi.org\/10.1002\/mds.23407","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.7942958.8807056","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.7942958.8302057","asserted-by":"object"}]},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"value":"0885-3185","type":"print"},{"value":"1531-8257","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,10,19]]}}}