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The insulin\/insulin\u2010like growth factor 1 (IGF\u20101) system (IIS) has been shown to play a role in the neurological dysfunction of SCAs and other polyglutamine disorders. We aimed to study the biomarker profile of serum IIS components in SCA3. We performed a case\u2013control study with 46 SCA3 patients and 42 healthy individuals evaluating the peripheral IIS profile (insulin, IGF\u20101, IGFBP1 and 3) and the correlation with clinical, molecular, and neuroimaging findings. SCA3 patients presented lower insulin and IGFBP3 levels and higher insulin sensitivity (HOMA2), free IGF\u2010I, and IGFBP1 levels when compared with controls. IGFBP\u20101 levels were directly associated with CAG expanded repeat length; IGF\u20101 was associated with the volumetries of specific brainstem regions on magnetic resonance imaging (MRI). Insulin levels and sensitivity were related to age at onset of symptoms. Our findings indicate an involvement of IIS components in SCA3 neurobiology and IGFBP\u20101 as a potential biomarker of the disease. \u00a9 2010 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.23428","type":"journal-article","created":{"date-parts":[[2010,11,10]],"date-time":"2010-11-10T13:45:28Z","timestamp":1289396728000},"page":"731-735","source":"Crossref","is-referenced-by-count":44,"title":["Serum insulin\u2010like system alterations in patients with spinocerebellar ataxia type 3"],"prefix":"10.1002","volume":"26","author":[{"given":"Jonas Alex Morales","family":"Saute","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew Chaves Feitosa","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre 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