{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:29:36Z","timestamp":1761006576999,"version":"build-2065373602"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,1,4]],"date-time":"2011-01-04T00:00:00Z","timestamp":1294099200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2011,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Background: Parkinson's disease (PD) and essential tremor (ET) may share some etiopathogenic factors. A genome\u2010wide association study has shown that <jats:italic>LINGO1<\/jats:italic> gene variants are associated with increased risk of ET. We hypothesized that <jats:italic>LINGO1<\/jats:italic> variants could increase susceptibility to PD. Methods: A large series of PD subjects and healthy controls were genotyped for rs9652490 and rs11856808 <jats:italic>LINGO1<\/jats:italic> single nucleotide polymorphisms (SNPs). Results: We found an increased frequency of the rs11856808<jats:sup>T\/T<\/jats:sup> genotype in PD compared with controls (odds ratio = 1.46; corrected <jats:italic>P<\/jats:italic> value = 0.02). A recessive genetic model was the best fit for rs11856808 influence on PD (recessive gene action test: corrected <jats:italic>P<\/jats:italic> value = 0.01). Stratification analysis showed that rs11856808<jats:sup>T\/T<\/jats:sup> genotype frequency was higher in the tremor\u2010dominant PD and the classical PD (C\u2010PD) subgroups (recessive gene action test for the C\u2010PD subgroup: corrected <jats:italic>P<\/jats:italic> value = 0.004). Discussion: Our results indicate that <jats:italic>LINGO1<\/jats:italic> variants could increase risk of PD, specifically those presenting the non\u2010rigid\u2010akinetic phenotypes, which suggests that <jats:italic>LINGO1<\/jats:italic> may have a role in the etiology of tremor in PD at least in the Spanish population. \u00a9 2010 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.23452","type":"journal-article","created":{"date-parts":[[2011,1,4]],"date-time":"2011-01-04T14:46:55Z","timestamp":1294152415000},"page":"722-727","source":"Crossref","is-referenced-by-count":17,"title":["<i>LINGO1<\/i> gene analysis in Parkinson's disease phenotypes"],"prefix":"10.1002","volume":"26","author":[{"given":"Oswaldo","family":"Lorenzo\u2010Betancor","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Llu\u00eds","family":"Samaranch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Garc\u00eda\u2010Mart\u00edn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebasti\u00e1n","family":"Cervantes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 A.G.","family":"Ag\u00fandez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F\u00e9lix J.","family":"Jim\u00e9nez\u2010Jim\u00e9nez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hortensia","family":"Alonso\u2010Navarro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Luengo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Coria","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Lorenzo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaione","family":"Irigoyen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pau","family":"Pastor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"The Iberian Parkinson's Disease Genetics Study Group Researchers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,1,4]]},"reference":[{"issue":"11","key":"e_1_2_7_2_2","first-page":"S21","article-title":"Prevalence of Parkinson's disease in Europe: a collaborative study of population\u2010based cohorts. Neurologic Diseases in the Elderly Research Group","volume":"54","author":"de Rijk MC","year":"2000","journal-title":"Neurology"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1586\/14737175.7.6.657"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.45.4.645"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.61.7.931"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2008.147223"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.62.6.1004"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm266"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.299"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn1188"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0700901104"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.55.3.181"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000285082.18969.3a"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bth457"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1086\/519795"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-008-0582-9"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/humu.20626"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1086\/430507"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181ae7af1"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-11-326"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2010.27"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22887"},{"journal-title":"Neurogenetics","article-title":"LINGO1 and LINGO2 variants are associated with essential tremor and Parkinson disease","author":"Vilarino\u2010Guell C","key":"e_1_2_7_23_2"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181bacfc9"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2009.08.006"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22768"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2010.01.055"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/28.2.99"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22829"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.63.8.1100"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2009.02784.x"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.23452","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.23452","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.23452","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T09:25:20Z","timestamp":1760952320000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.23452"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1,4]]},"references-count":30,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011,3]]}},"alternative-id":["10.1002\/mds.23452"],"URL":"https:\/\/doi.org\/10.1002\/mds.23452","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"type":"print","value":"0885-3185"},{"type":"electronic","value":"1531-8257"}],"subject":[],"published":{"date-parts":[[2011,1,4]]}}}