{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T14:36:15Z","timestamp":1791210975388,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2011,2,10]],"date-time":"2011-02-10T00:00:00Z","timestamp":1297296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2011,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background:<\/jats:title><jats:p>Abnormal repetitive behaviors have been reported in Parkinson's disease (PD) during dopamine replacement therapy (DRT) and associated with individual predisposing features, including impulsivity. However, impulsivity and compulsive symptoms have never been explored in PD patients before initiation of DRT. We previously reported a 20% of impulse control disorders (ICD) in an Italian cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>103 consecutive newly diagnosed drug\u2010na\u00efve PD patients (means: age = 60.5 \u00b1 9.2 years; duration = 15.4 \u00b1 15.3 months) were screened for compulsive sexual behavior, compulsive buying, intermittent explosive disorder (Minnesota Impulsive Disorders Interview, MIDI), and pathological gambling (South Oaks Gambling Screen, SOGS). Barratt Impulsiveness Scale (BIS\u201011) and Maudsley Obsessional\u2010Compulsive Questionnaire (MOCQ\/R) assessed impulsivity, obsessive\u2010compulsive symptoms, respectively. Depression (GDS\u201015) and general cognitive status were additionally assessed. We also compared ICDs frequency with our healthy controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>17.5% of PD patients screened positive for at least one ICD at MIDI (17\/103) and SOGS (1\/103), though none had a disorder based on DSM\u2010IV criteria. These frequencies were similar to healthy controls. There was a trend toward higher scores in BIS\u201011 attentive\u2010impulsivity subscale (15.2 \u00b1 4.8 vs. 18.7 \u00b1 4.9; <jats:italic>P<\/jats:italic> = 0.007) and in MOCQ\/R\u2010Doubting subscale (0.67 \u00b1 1.1 vs. 1.5 \u00b1 1.2; <jats:italic>P<\/jats:italic> = 0.007) in PD with ICD. We also observed a positive correlation between GDS\u201015 and BIS\u201011.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>Similar to our healthy control population, we found a significant proportion of early PD patients positive for ICDs before starting treatment. We also found a relationship between impulsivity and depression. A detailed behavioral assessment before starting dopaminergic therapy is recommended. \u00a9 2011 Movement Disorder Society<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.23501","type":"journal-article","created":{"date-parts":[[2011,2,10]],"date-time":"2011-02-10T19:02:52Z","timestamp":1297364572000},"page":"464-468","source":"Crossref","is-referenced-by-count":149,"title":["Impulsivity and compulsivity in drug\u2010na\u00efve patients with Parkinson's disease"],"prefix":"10.1002","volume":"26","author":[{"given":"Angelo","family":"Antonini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Siri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"Santangelo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Cilia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Poletti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margherita","family":"Canesi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Caporali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Mancini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianni","family":"Pezzoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Ceravolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ubaldo","family":"Bonuccelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Barone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,2,10]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.64.8.1089"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.62.9.noc50009"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.63.7.969"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21611"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21872"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2010.65"},{"key":"e_1_2_7_8_2","first-page":"5","article-title":"Compulsive buying: descriptive characteristics and psychiatric comorbidity","volume":"55","author":"Christenson GA","year":"1994","journal-title":"J Clin Psychiatry"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.144.9.1184"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/jclp.1051"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0005-7967(77)90042-0"},{"key":"e_1_2_7_12_2","first-page":"165","volume-title":"Clinical gerontology: a guide to assessment and intervention","author":"Sheikh JI","year":"1986"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-005-0443-4"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890423349"},{"key":"e_1_2_7_16_2","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1176\/ps.49.11.1434","article-title":"Clinical features and psychiatric comorbidity of subjects with pathological gambling behavior","volume":"49","author":"Black DW","year":"1998","journal-title":"Psychiatry Serv"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.162.11.2184"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-4679(199511)51:6<768::AID-JCLP2270510607>3.0.CO;2-1"},{"key":"e_1_2_7_19_2","volume-title":"CBA 2.0. 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