{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T14:46:10Z","timestamp":1772549170817,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,2,1]],"date-time":"2011-02-01T00:00:00Z","timestamp":1296518400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2011,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background:<\/jats:title><jats:p>Previous studies have explored the efficacy and safety of botulinum neurotoxin (BoNT) treatment for Focal hand dystonia (FHD), but none have followed a large number of patients for 10 years or more.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>Retrospective study, with benefit and weakness assessed on a 0 to 4 subjective scale. Demographic, clinical and treatment characteristics were analyzed using <jats:italic>t<\/jats:italic> tests and Pearson correlations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>Twenty FHD patients had 10 years or longer treatment. Interinjection intervals were variable. Musicians were more likely to wait longer between injections and had less complex dystonia. There was a trend for larger benefit in women and with shorter intervals. The dose increased over time. Dystonia characteristics did not predict response or side\u2010effects, but benefit magnitude predicted longer compliance. No serious side\u2010effects or antibody\u2010mediated resistance occurred.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p>This is the longest reported period of BoNT treatment in the largest FHD cohort. BoNT therapy for FHD remains safe and effective after more than a decade of treatment. \u00a9 2011 Movement Disorder Society<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.23504","type":"journal-article","created":{"date-parts":[[2011,2,1]],"date-time":"2011-02-01T13:42:43Z","timestamp":1296567763000},"page":"750-753","source":"Crossref","is-referenced-by-count":71,"title":["Long\u2010term follow\u2010up of botulinum toxin therapy for focal hand dystonia: Outcome at 10 years or more"],"prefix":"10.1002","volume":"26","author":[{"given":"Codrin","family":"Lungu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara I.","family":"Karp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharine","family":"Alter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Regina","family":"Zolbrod,","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Hallett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,2]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/105.3.461"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2005.083170"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000311389.26145.95"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2004.12.012"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.44.1.70"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20025"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.52.3.355"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20376"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.10252"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2006.01652.x"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.51.5.1494"},{"issue":"10","key":"e_1_2_5_13_2","first-page":"923","article-title":"[Problems of treating writer's cramp with botulinum toxin injections: results from 10 years of experience]","volume":"159","author":"Marion MH","year":"2003","journal-title":"Rev Neurol (Paris)"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.42.3.627"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.42.4.878"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.58.5.805"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00839202"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870060110"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22255"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jht.2008.11.006"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870100411"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000055087.96356.BB"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.45.9.1743"},{"key":"e_1_2_5_24_2","doi-asserted-by":"crossref","unstructured":"HallettM BeneckeR BlitzerA ComellaCL.Toxicon.2009.54(5):628\u2013633.","DOI":"10.1016\/j.toxicon.2008.12.008"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03033933"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.23504","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.23504","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.23504","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T09:25:19Z","timestamp":1760952319000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.23504"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,2]]},"references-count":24,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011,3]]}},"alternative-id":["10.1002\/mds.23504"],"URL":"https:\/\/doi.org\/10.1002\/mds.23504","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"value":"0885-3185","type":"print"},{"value":"1531-8257","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,2]]}}}