{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T09:18:28Z","timestamp":1793092708509,"version":"4.5.0"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,2,10]],"date-time":"2011-02-10T00:00:00Z","timestamp":1297296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2011,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Deep brain stimulation of the globus pallidus internus (GPi DBS) is effective in the treatment of primary segmental and generalized dystonia. Although limb, neck, or truncal dystonia are markedly improved, orofacial dystonia is ameliorated to a lesser extent. Nevertheless, several case reports and small cohort studies have described favorable short\u2010term results of GPi DBS in patients with severe Meige syndrome. Here, we extend this preliminary experience by reporting long\u2010term outcome in a multicenter case series, following 12 patients (6 women, 6 men) with Meige syndrome for up to 78 months after bilateral GPi DBS. We retrospectively assessed dystonia severity based on preoperative and postoperative video documentation. Mean age of patients at surgery was 64.5 \u00b1 4.4 years, and mean disease duration 8.3 \u00b1 4.4 years. Dystonia severity as assessed by the Burke\u2013Fahn\u2013Marsden Dystonia Rating Scale showed a mean improvement of 45% at short\u2010term follow\u2010up (4.4 \u00b1 1.5 months;\u00a0\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.001) and of 53% at long\u2010term follow\u2010up (38.8 \u00b1 21.7 months;\u00a0\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.001). Subscores for eyes were improved by 38% (\n                    <jats:italic>P<\/jats:italic>\n                    =\u00a00.004) and 47% (\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.001), for mouth by 50% (\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.001) and 56% (\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.001), and for speech\/swallowing by 44% (\n                    <jats:italic>P<\/jats:italic>\n                    = 0.058) and 64% (\n                    <jats:italic>P<\/jats:italic>\n                    = 0.004). Mean improvements were 25% (\n                    <jats:italic>P<\/jats:italic>\n                    = 0.006) and 38% (\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.001) on the Blepharospasm Movement Scale and 44% (\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.001) and 49% (\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.001) on the Abnormal Involuntary Movement Scale. This series, which is the first to demonstrate a long\u2010term follow\u2010up in a large number of patients, shows that GPi DBS is a safe and highly effective therapy for Meige syndrome. The benefit is preserved for up to 6 years. \u00a9 2011 Movement Disorder Society\n                  <\/jats:p>","DOI":"10.1002\/mds.23549","type":"journal-article","created":{"date-parts":[[2011,2,10]],"date-time":"2011-02-10T19:01:40Z","timestamp":1297364500000},"page":"691-698","source":"Crossref","is-referenced-by-count":130,"title":["Long\u2010term clinical outcome in meige syndrome treated with internal pallidum deep brain stimulation"],"prefix":"10.1002","volume":"26","author":[{"given":"Ren\u00e9","family":"Reese","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doreen","family":"Gruber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Schoenecker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hansj\u00f6rg","family":"B\u00e4zner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Blahak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. 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