{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T18:12:27Z","timestamp":1760983947511,"version":"build-2065373602"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2011,3,7]],"date-time":"2011-03-07T00:00:00Z","timestamp":1299456000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2011,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background:<\/jats:title><jats:p>The objective of this study was to evaluate whether the sensation of thirst differs between patients with progressive supranuclear palsy (PSP), multiple system atrophy with predominant parkinsonism (MSA\u2010P), and Parkinson's disease (PD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>We administered a standardized thirst questionnaire to age\u2010, sex\u2010, and stage\u2010matched patients with probable PSP, PD, and MSA\u2010P and healthy controls (HC), n = 15\/group. In an independent cohort (n = 10\/group), we provoked thirst by infusing hypertonic NaCl in age\u2010, sex\u2010, and stage\u2010matched patients with PSP, PD, and MSA\u2010P and recorded plasma osmolality and thirst (visual analog scale).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>On questioning, 73% of PSP patients reported a reduced sensation of thirst (hypodipsia) compared with previous years (HC, 0%; PD, 7%; MSA\u2010P, 7%; <jats:italic>P<\/jats:italic> &lt; .0001). On NaCl infusion, PSP patients reported significantly lower thirst than did PD and MSA\u2010P patients for all times from 20 to 95 minutes (<jats:italic>P<\/jats:italic> &lt; .05). The thirst score at 25 minutes discriminated individual PSP patients well from PD and MSA\u2010P patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>Hypodipsia appears helpful in differentiating PSP from PD and MSA\u2010P. \u00a9 2011 Movement Disorder Society<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.23587","type":"journal-article","created":{"date-parts":[[2011,3,7]],"date-time":"2011-03-07T18:32:53Z","timestamp":1299522773000},"page":"901-905","source":"Crossref","is-referenced-by-count":3,"title":["Hypodipsia discriminates progressive supranuclear palsy from other parkinsonian syndromes"],"prefix":"10.1002","volume":"26","author":[{"given":"Maria","family":"Stamelou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helena","family":"Christ","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Reuss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Oertel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00fcnter","family":"H\u00f6glinger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,3,7]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.47.1.1"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(02)00161-8"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2009.196"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70042-0"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.10680"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.51.6.745"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000324625.00404.15"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.17.5.427"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0749-0690(02)00059-9"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.134.4.382"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.55.11.1621"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20160"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22289"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-007-0626-8"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/120.1.111"},{"key":"e_1_2_5_17_2","first-page":"538","article-title":"Acquired disorder of thirst perception with intact osmoregulation of vasopressin","volume":"110","author":"Z\u00fcnd S","year":"1998","journal-title":"Wien Klin Wochenschr"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-198906000-00011"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21204"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awn195"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.63.1.81"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-006-0344-7"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/PL00007758"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.9.5304"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2136650100"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0511019103"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.5.2532"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00869.2007"},{"key":"e_1_2_5_29_2","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/S0022-3565(25)23811-3","article-title":"Polydipsia and dopamine: behavioral effects of dopamine D1 and D2 receptor agonists and antagonists","volume":"271","author":"Mittleman G","year":"1994","journal-title":"J Pharmacol Exp Ther"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.23587","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.23587","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.23587","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T08:59:38Z","timestamp":1760950778000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.23587"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,3,7]]},"references-count":28,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2011,4]]}},"alternative-id":["10.1002\/mds.23587"],"URL":"https:\/\/doi.org\/10.1002\/mds.23587","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"type":"print","value":"0885-3185"},{"type":"electronic","value":"1531-8257"}],"subject":[],"published":{"date-parts":[[2011,3,7]]}}}