{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T22:59:30Z","timestamp":1777417170992,"version":"3.51.4"},"reference-count":34,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2011,4,19]],"date-time":"2011-04-19T00:00:00Z","timestamp":1303171200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2011,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The purpose of this study was to evaluate the possible association of cigarette smoking, coffee drinking, and wine consumption with essential tremor using a matched case\u2013control design. Cases and controls were enrolled from 6 Movement Disorder centers in central\u2010southern Italy. Essential tremor was diagnosed according to Bain's criteria. Three unrelated healthy controls (not affected by neurological disorders) per each enrolled case, matched by sex and age (\u00b15 years), were selected. A standardized questionnaire was administered to record demographic, epidemiological, and clinical data. All cases and controls underwent a standard neurological examination. Adjusted odds ratios and 95% confidence intervals were estimated using conditional logistic regression for the matched cases and controls. Eighty\u2010three patients with essential tremor (38 men and 45 women; mean age, 68.2 \u00b1 8.6 years) and 245 matched control subjects (113 men and 132 women; mean age, 68.4 \u00b1 9.7 years) were enrolled in the study. Multivariate analysis showed a significant negative association between essential tremor and wine consumption preceding the onset of disease (adjusted odds ratio, 0.23; 95% confidence interval, 0.08\u20130.64; <jats:italic>P<\/jats:italic> = .0005) with a significant dose effect (1\u20132 glass of wine per day: odds ratio, 0.32; 95% confidence interval, 0.10\u20130.95; <jats:italic>P<\/jats:italic> = .04; more than 3 glass of wine per day: odds ratio, 0.14; 95% confidence interval, 0.03\u20130.62; <jats:italic>P<\/jats:italic> = .01). In our sample no association between essential tremor and cigarette smoking or coffee drinking was found. Our data suggest a negative association between wine drinking and essential tremor, which could be explained by the long\u2010term neuroprotective effect of its antioxidant components. \u00a9 2011 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.23603","type":"journal-article","created":{"date-parts":[[2011,4,20]],"date-time":"2011-04-20T07:59:56Z","timestamp":1303286396000},"page":"1310-1315","source":"Crossref","is-referenced-by-count":7,"title":["Wine drinking and essential tremor: A possible protective role"],"prefix":"10.1002","volume":"26","author":[{"given":"Alessandra","family":"Nicoletti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Mostile","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Cappellani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donatella","family":"Contrafatto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gennarina","family":"Arabia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Lamberti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Marconi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Letterio","family":"Morgante","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Barone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aldo","family":"Quattrone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Zappia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,4,19]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.10221"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22838"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22755"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2008.147223"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21584"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm266"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2009.217"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2007.8"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1159\/000151523"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(06)70471-9"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-009-0182-z"},{"issue":"4","key":"e_1_2_6_13_2","first-page":"S7","article-title":"Criteria for the diagnosis of essential tremor","volume":"54","author":"Bain P","year":"2000","journal-title":"Neurology."},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/34.5.773"},{"key":"e_1_2_6_15_2","volume-title":"STATA statistical software: release 10.0","author":"Stata corp."},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1159\/000103646"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00713856"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2006.09.007"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1159\/000111579"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21810"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000311271.42596.32"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20035"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000145600.91491.F2"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2008.162701"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23240"},{"key":"e_1_2_6_26_2","volume-title":"Substance Abuse and Mental Health Services Administration. 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