{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T14:28:57Z","timestamp":1788186537599,"version":"build-2803163510"},"reference-count":46,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2011,4,5]],"date-time":"2011-04-05T00:00:00Z","timestamp":1301961600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2011,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Incidence rates of Parkinson's disease are higher in men than in women at all ages, and these differences may be a result of the neuroprotective effects of estrogen on the nigrostriatal pathway. We investigated the association of common variants in 4 estrogen\u2010related genes with Parkinson's disease. Tagging single\u2010nucleotide polymorphisms in the <jats:italic>CYP19A1<\/jats:italic>, <jats:italic>ESR1<\/jats:italic>, <jats:italic>ESR2<\/jats:italic>, and <jats:italic>PRDM2<\/jats:italic> genes were selected from the International Haplotype Map and genotyped in 1103 Parkinson's disease cases from the upper Midwest of the United States and in 1103 individually matched controls (654 unaffected siblings, and 449 unrelated controls from the same region). Of 137 informative single\u2010nucleotide polymorphisms, 2 <jats:italic>PRDM2<\/jats:italic> single\u2010nucleotide polymorphisms were significantly associated with an increased risk of Parkinson's disease at the Bonferroni\u2010corrected significance level of 0.0004 (rs2744690: OR, 1.54; SE(logOR), .109; 99.96% CI, 1.05\u20132.26; uncorrected <jats:italic>P<\/jats:italic> = .0001; rs2744687: OR, 1.53; SE(logOR), .113; 99.96% CI, 1.03\u20132.29, uncorrected <jats:italic>P<\/jats:italic> = .0002); the association was significant in the women\u2010only stratum but not in the men\u2010only stratum. An additional 6 single\u2010nucleotide polymorphisms in <jats:italic>PRDM2<\/jats:italic>, 2 in <jats:italic>ESR1<\/jats:italic>, 1 in <jats:italic>ESR2<\/jats:italic>, and 1 in <jats:italic>CYP19A1<\/jats:italic> had significant <jats:italic>P<\/jats:italic> values in the overall sample before Bonferroni correction. None of the single\u2010nucleotide polymorphisms were significantly associated with age at onset of Parkinson's disease after Bonferroni correction. Our results confirm the association of <jats:italic>PRDM2<\/jats:italic> variants with Parkinson's disease susceptibility, especially in women. \u00a9 2011 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.23604","type":"journal-article","created":{"date-parts":[[2011,4,5]],"date-time":"2011-04-05T17:21:47Z","timestamp":1302024107000},"page":"1234-1242","source":"Crossref","is-referenced-by-count":23,"title":["Variants in estrogen\u2010related genes and risk of Parkinson's disease"],"prefix":"10.1002","volume":"26","author":[{"given":"Sun Ju","family":"Chung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian M.","family":"Armasu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna M.","family":"Biernacka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy G.","family":"Lesnick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David N.","family":"Rider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie M.","family":"Cunningham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Demetrius M.","family":"Maraganore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,4,5]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(01)00425-5"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.52.6.1214"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.55.9.1358"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.1996.tb00877.x"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(97)00437-X"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(96)12760-9"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.20124"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1998.tb08230.x"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2007.01.020"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(97)00630-6"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200301200-00009"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(01)00014-8"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-003-0045-3"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0892-0362(96)00086-4"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1996.66020658.x"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-23-08604.2000"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.1170"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.52.7.1417"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.61.6.886"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000280573.30975.6a"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.84.9.3146"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.1253"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1086\/496902"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000152585.76852.9C"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(98)00017-1"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a113955"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a116946"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000304049.31377.f2"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2008.11.011"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1006\/frne.2000.0207"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature04226"},{"key":"e_1_2_7_33_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bth457"},{"key":"e_1_2_7_34_2","first-page":"5","article-title":"Statistical methods in cancer research. 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